May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Corneal thickness and intraocular pressure in Singapore children
Author Affiliations & Notes
  • L.M. Tong
    Ophthalmology, Singapore National Eye Center, Singapore, Singapore
    Singapore Eye Research Institute, Singapore, Singapore
  • S. Saw
    Singapore Eye Research Institute, Singapore, Singapore
    Community Occupational and Family Medicine,
    National University of Singapore, Singapore, Singapore
  • G. Gazzard
    Singapore Eye Research Institute, Singapore, Singapore
    Glaucoma Research Unit, Moorfields Eye Hospital, London, United Kingdom
  • J.–K. Siak
    Community Occupational and Family Medicine,
    National University of Singapore, Singapore, Singapore
  • D. Tan
    Ophthalmology, Singapore National Eye Center, Singapore, Singapore
    Ophthalmology,
    National University of Singapore, Singapore, Singapore
  • Footnotes
    Commercial Relationships  L.M. Tong, None; S. Saw, None; G. Gazzard, None; J. Siak, None; D. Tan, None.
  • Footnotes
    Support  NMRC/0695/2002
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4496. doi:
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    • Get Citation

      L.M. Tong, S. Saw, G. Gazzard, J.–K. Siak, D. Tan; Corneal thickness and intraocular pressure in Singapore children . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4496.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To determine the central cornea thickness(CCT) in Singapore children and to examine the possible relationship between intraocular pressure (IOP) and other biometric factors and CCT. Methods: This is a cross sectional study obtained from the Singapore Cohort study Of the Risk factors for Myopia (SCORM) in Singapore. The subjects’ ages (n=652) ranged from 9 to 11 years old. There were 485 Chinese, 92 Malay and 75 Asian Indian children. Measurement procedures included air puff tonometry, non–contact slit lamp Haag Streit optical pachymetry, cycloplegic autorefraction and autokeratometry using the Canon RK5 autorefractokeratometer.. The test–retest repeatability of pachymetry was –0.04 microns (95%CI: –5.33 to +5.25). Results: The mean corneal thickness was 543.6 microns (SD: 32.0). Chinese children have thicker corneas than Malay or Indian children (p=0.002). The boys had a statistically thicker cornea than girls (p=0.011), but the mean difference was only 6.4 microns. There was high correlation of CCT (r=0.98) and IOP(r=0.88) between right and left eyes. IOP was correlated significantly with CCT (r = 0.45, p<0.001). CCT increased from a mean of 527.2 microns in the first IOP quartile (10.7–15.3 mmHg) to 563.7 microns in the highest IOP quartile (19.1–24.7 mmHg). In a multiple linear regression model, each mmHg of intraocular pressure was associated with a corneal thickness difference of 5.90 microns (95%CI: 4.98, 6.82).Interestingly, the radius of corneal curvature was correlated inversely with CCT (r=0.19, p<0.001). The following parameters were not significantly (p>0.05) associated with CCT: age, family income, father’s education, axial length and spherical equivalent. Conclusions: The study supports previous findings in adults that there is a definite relationship between greater CCT and higher measured IOP. A change in CCT appeared to correlate with a greater difference in measured IOP compared to adults. There is a greater CCT in Chinese children compared to Malay and Asian Indian children in thismulti–ethnic population.

Keywords: clinical (human) or epidemiologic studies: prevalence/incidence • visual development: infancy and childhood • cornea: basic science 
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