May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Association between Corneal Thickness, Intraocular pressure, and Disease Stability in Primary Open Angle Glaucoma
Author Affiliations & Notes
  • J.H. Walker
    Faculty Business, Brock University, St Catherines, ON, Canada
    PharmIdeas Research and Consulting Inc., Oakville, ON, Canada
  • Y. Buys
    Department of Ophthalmology,
    University of Toronto, Toronto, ON, Canada
  • G.E. Trope
    Department of Ophthalmology,
    University of Toronto, Toronto, ON, Canada
  • C. Vicente
    PharmIdeas Research and Consulting Inc., Oakville, ON, Canada
  • T.R. Einarson
    PharmIdeas Research and Consulting Inc., Oakville, ON, Canada
    Faculty of Pharmacy,
    University of Toronto, Toronto, ON, Canada
  • D. Covert
    Alcon Research, Ltd, Fort Worth, TX
  • M. Iskedjian
    PharmIdeas Research and Consulting Inc., Toronto, ON, Canada
  • Footnotes
    Commercial Relationships  J.H. Walker, None; Y. Buys, None; G.E. Trope, None; C. Vicente, None; T.R. Einarson, None; D. Covert, Alcon Research, Ltd E; M. Iskedjian, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4497. doi:
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      J.H. Walker, Y. Buys, G.E. Trope, C. Vicente, T.R. Einarson, D. Covert, M. Iskedjian; Association between Corneal Thickness, Intraocular pressure, and Disease Stability in Primary Open Angle Glaucoma . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4497.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: A retrospective analysis was performed to compare the mean corneal thickness (CT) by the level of visual field mean defect (VF) severity. In addition, the relationship between CT, intra–ocular pressure (IOP), and disease stability was examined. Methods: Two practices within a glaucoma clinic were used to collect data on patients diagnosed with Primary Open–Angle glaucoma (POAG) using ICD–9 code 365.11. VF scores, IOP measurements, physician impressions, and resources used (physician visits, procedures, and medications) were recorded over a minimum of 2.5 years. CT measures were extracted from the patient charts to determine the mean CT when stratifying patients by VF severity. The VF severity levels included mild (0 to –5 dB), moderate (<–5 to > –12 dB), and severe (< –12 dB). The Mann–Whitney U test was performed on the null hypothesis that the mean CT is equal amongst the three VF severity levels. Multiple regression analyses were also performed by VF severity to determine the association between disease stability, IOP, and CT. Results: Of the 265 charts included in our original analysis, 99 charts included CT measures. Patient distribution included 36 with mild, 31 with moderate, and 32 with severe disease. The mean CT of the overall, mild, moderate, and severe groups was 545.9 µm, 561.8 µm, 548.9 µm, and 525.1 µm, respectively. The Mann–Whitney U test produced statistically significant difference (p<0.05) between the mean CT of the mild and severe groups. A relationship was present between VF severity level and mean CT. Results of the regression analyses suggest that IOP and CT may be predictors of disease stability. Conclusions: Results of this analysis suggest that patients with severe VF scores tend to have thinner corneas. Further research is warranted to examine the association between corneal thickness and disease progression.

Keywords: clinical (human) or epidemiologic studies: risk factor assessment • intraocular pressure • visual fields 
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