May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Glaucoma and Compliance: Comparison of objective patient compliance information with respect to "QD" dosing versus "BID" dosing on patient medication compliance.
D.J. Blair; L. Cantor; D. WuDunn; J. Hoop; V. Malinovsky
Author Affiliations & Notes
  • D.J. Blair
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • L. Cantor
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • D. WuDunn
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • J. Hoop
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • V. Malinovsky
    Optometry, Indiana University School of Optometry, Bloomington, IN
  • Footnotes
    Commercial Relationships  D.J. Blair, None; L. Cantor, None; D. WuDunn, None; J. Hoop, None; V. Malinovsky, None.
  • Footnotes
    Support  Supported in part by Allergan, Inc. and in part by an unrestricted grant from RPB, Inc.
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4510. doi:
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      D.J. Blair, L. Cantor, D. WuDunn, J. Hoop, V. Malinovsky; Glaucoma and Compliance: Comparison of objective patient compliance information with respect to "QD" dosing versus "BID" dosing on patient medication compliance. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4510.

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Abstract

Abstract: : Purpose: To compare the effect of "once a day" versus "twice a day dosing’ on patient medication compliance with glaucoma topical therapy. Methods: 100 patients were enrolled in this prospective series utilizing two different medication regimens. Group A (50 patients) were on glaucoma topical medication dosed once a day "QD" and group B (50 patients) were on eyedrops dosed twice a day, "BID". All patients signed consent allowing release of their refill data from their local pharmacy. If a patient refilled their medication as expected given their prescribed dosing regimen and bottle size, their rate of compliance would be 100%. If they refilled their medications less frequently or more frequently than expected their compliance rate would be below or above 100% respectively Calculated drops per bottle were obtained from a national pharmacy benefit manager. Allowing for some variation in dosing, we considered 85% to 115% utilization to reflect acceptable compliance with the prescribed regimen. Results: 20 patients (10 from each group) either withdrew or were not included due to insufficient data collection. Compliance rates of Group A varied from 31.9% to 429.6 %. Compliance rates for group B varied from 33.7% to 230.3%. Average differences between the two groups were not significantly different. Group A patients (QD) exhibited a 25.0 % over utilization rate as compared with a 30.0% over utilization rate for group B patients (BID). Group A patients (QD) exhibited a 37.5 % under utilization rate as compared with a 27.5% under utilization rate for group B patients (BID). Conclusions: This study provides evidence that compliance rates between once a day dosing versus twice a day dosing is similar.

Keywords: clinical (human) or epidemiologic studies: biostatistics/epidemiology methodology • clinical (human) or epidemiologic studies: health care delivery/economics/manpower • pharmacology 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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