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E. Ferrari, D. Roman Pognuz, F. Pea, F. Pavan, L. Morgante, F. Bandello, M. Furlanut; Aqueous Pharmacokinetics of Levofloxacin after Oral Administration . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4553.
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Purpose: To evaluate intraocular penetration and the pharmacokinetic parameters of levofloxacin into the aqueous humor and plasma after oral administration, and describe the concentration curves. Methods: 45 eyes of 45 patients undergoing cataract surgery were enrolled. Aqueous and serum samples were obtained and later analyzed from each patient after oral administration of two 500–mg tablets. Levofloxacin was administered, respectively, the night before at 9.00 PM and at 7.00 AM the day of surgery. Patients were divided into eight groups. Aqueous and plasma samples were obtained at 105±15, 135±15, 165±15, 195±15, 225±15, 255±15, 285±15, 315±15 minutes from last tablet administration. Aqueous and serum concentration were measured by high–performance liquid chromatography. Results:
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