May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
The effect of ganglionic blockade on the relationship between ciliary blood flow and aqueous production in the rabbit.
Author Affiliations & Notes
  • J.W. Kiel
    Ophthalmology, Univ of TX Hlth Science Center, San Antonio, TX
  • Footnotes
    Commercial Relationships  J.W. Kiel, None.
  • Footnotes
    Support  NIH Grant EY09702
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4668. doi:
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      J.W. Kiel; The effect of ganglionic blockade on the relationship between ciliary blood flow and aqueous production in the rabbit. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4668.

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Abstract

Abstract: : Purpose: To quantify the relationship between ciliary blood flow and aqueous production under ganglionic blockade conditions in an animal model. Methods: In pentobarbital anesthetized rabbits, mean arterial pressure (MAP) and intraocular pressure were measured by direct cannulation. In Group 1 (n=28), aqueous flow was measured by fluorophotometry. In Group 2 (n=23), ciliary blood flow was measured by laser Doppler flowmetry. Measurements in both groups were made under ganglionic blockade conditions (hexamethonium, 50 mg/ml infused at 1.5 ml/hr) for 60 min while MAP was set at 30, 40, 55, 70 or 80 mmHg with occluders on the vena cava and aorta. Results: Ganglionic blockade causes ciliary vasodilation and shifts the ciliary pressure–flow relationship upwards; however, it does not markedly alter the relationship between ciliary blood flow and aqueous production (dashed line in figure shows control relationship from IOVS 2003;44:3967–3971). Conclusions: In the anesthetized rabbit under control conditions, aqueous production becomes blood flow–dependent when ciliary perfusion falls below 70% of its control value; at higher blood flow rates, aqueous production is independent of blood flow. Removal of autonomic neural input to the eye does not alter this relationship.  

Keywords: blood supply • ciliary body • pharmacology 
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