Abstract
Abstract: :
Purpose: To study morphological changes in mucosal membrane of distal portion of stenotic lacrimonasal duct. Methods: Histological analysis of: 1) 16 cadaveric macropreparations of lacrimonasal duct with tissue of inferior meatus of the nose taken as a single fragment from cadavers with occurred during lifetime history of untreated chronic dacryostenosis; 2) 118 biopsy fragments of mucosal membrane of nasal portion of lacrimonasal duct taken during endoscopy of inferior meatus of the nose from 88 patients with epiphora. Results: All cases of dacryostenosis were characterized by such pathological changes in mucosa as disintegration and desquamation of ciliated epithelium, metaplasia, cast–off epithelium and sclerotic tissue formation. Statistically significant strong correlation between clinical forms of dacryostenosis, dacryoendoscopic picture of mucosal changes and pronouncement of morphological changes has been established. According to received data three groups of typical pathological changes in dacryostenosis have been revealed: 1) significant enlargement of Hasner’s fold resulted in intraepithelial oedema and loss of ciliated epithelial cells complement; 2) tight contiguity between across portions of nasal mucosa of lacrimonasal duct was accompanied by glandular oversecretion and focal epithelial desquamation; 3) obliteration of lacrimonasal duct led to hyalinosis of basement membrane and fibrotic and sclerotic tissue degeneration. Conclusions: Endoscopically revealed changes in mucosa of inferior meatus of the nose correspond to morphological changes in mucosa of lacrimonasal duct and represent the links of the one process of lacrimonasal duct obliteration.
Keywords: pathology: human • inflammation • clinical (human) or epidemiologic studies: outcomes/complications