May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Growth Factor Receptor Expression in Orbital Lymphangioma: Possible Therapeutic Implications
R. Diba; R. Gonnering; V.G. Prieto; H.G. Saadati; M.A. Ahmadi; T.R. Shepler; M.J. Hawes; Z. Karcioglu; B. Esmaeli
Author Affiliations & Notes
  • R. Diba
    Section of Ophthalmology/Department of Plastic Surgery,
    The University of Texas MD Anderson Cancer Center, Houston, TX
  • R. Gonnering
    The Eye Institute, The Medical College of Wisconsin, Milwaukee, WI
  • V.G. Prieto
    Department of Pathology,
    The University of Texas MD Anderson Cancer Center, Houston, TX
  • H.G. Saadati
    Section of Ophthalmology/Department of Plastic Surgery,
    The University of Texas MD Anderson Cancer Center, Houston, TX
  • M.A. Ahmadi
    Section of Ophthalmology/Department of Plastic Surgery,
    The University of Texas MD Anderson Cancer Center, Houston, TX
  • T.R. Shepler
    Section of Ophthalmology/Department of Plastic Surgery,
    The University of Texas MD Anderson Cancer Center, Houston, TX
  • M.J. Hawes
    Department of Ophthalmology, The University of Colorado, Denver, CO
  • Z. Karcioglu
    Department of Ophthalmology, Tulane University, New Orleans, LA
  • B. Esmaeli
    Section of Ophthalmology/Department of Plastic Surgery,
    The University of Texas MD Anderson Cancer Center, Houston, TX
  • Footnotes
    Commercial Relationships  R. Diba, None; R. Gonnering, None; V.G. Prieto, None; H.G. Saadati, None; M.A. Ahmadi, None; T.R. Shepler, None; M.J. Hawes, None; Z. Karcioglu, None; B. Esmaeli, None.
  • Footnotes
    Support  n/a
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4690. doi:
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      R. Diba, R. Gonnering, V.G. Prieto, H.G. Saadati, M.A. Ahmadi, T.R. Shepler, M.J. Hawes, Z. Karcioglu, B. Esmaeli; Growth Factor Receptor Expression in Orbital Lymphangioma: Possible Therapeutic Implications . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4690.

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Abstract

Abstract: : Purpose:To examine the expression of molecules targeted by imatinib mesylate (STI571;Gleevec) and epidermal growth factor receptor (EGFR) inhibitors in orbital lymphangiomas. Methods:Tissue specimens and medical records from six patients with orbital lymphangioma treated at four institutions between March 2000 and December 2002 were collected and reviewed. Immunohistochemical analysis was performed using antibodies against c–kit and platelet–derived growth factor receptor (PDGFR) alpha and beta and EGFR tyrosine kinase. Results:PDGFR alpha and beta receptors were expressed on the endothelial, perithelial (pericytes), and smooth muscle cells of the vascular channels of the lymphangioma in all six patients. Five of six orbital specimens demonstrated expression of EGFR on the pericytes and smooth muscle cells of the vascular channels. C–kit was expressed by mast cells. Conclusions:PDGFR expression by the endothelial cells lining orbital lymphangiomas suggests a possible role for PDGF in the angiogenic activity of this tumor. Clinical trials should be designed to investigate the efficacy of specific inhibitors of PDGFR, such as imatinib mesylate, as single agents or in combination with EGFR inhibitors for treatment of refractory orbital lymphangioma.

Keywords: growth factors/growth factor receptors • orbit • tumors 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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