Clinical, Histopathologic and Ultrastructural Features of Corneal Keloid

Abstract

Abstract: : Purpose: To describe the clinical, histopathologic and ultrastructural findings of anomalous corneal cicatrization process (keloids) in a large Mexican Ophthalmological reference center. Methods: All the cases were reviewed from the archives of the Ophthalmic Pathology Department of the APEC (1957–2003). The sections of all cases were stained with H&E, Massons Trichrome and the electron microscopy of one case was performed. Results: There were 2 women and 2 men with a mean age of 12 years. The right eye was involved in 3 cases. History of ocular surgery was present in 3 cases. The histopathologic features in all cases consisted of broad haphazardly arranged collagen fascicles with activated fibroblasts. Iris tissue was present within the scars in all cases. Ultrastructural findings showed randomly oriented lamellae of collagen fibers. Conclusions: Corneal keloid is suspected in cases of an elevated glistening white mass. The final diagnosis is confirmed by histopathologic study.

Keywords: pathology: human • cornea: stroma and keratocytes • cornea: basic science