Gatifloxacin 0.3% compared to Ciprofloxacin 0.3% to prevent Mycobacterial Keratitis in an animal model

Abstract

Abstract: : Purpose: To compare the efficacy of gatifloxacin ophthalmic solution 0.3% to ciprofloxacin ophthalmic solution 0.3% in preventing mycobacterial keratitis after creating a flap in an animal model. Methods: In 25 eyes of 15 New Zealand rabbits a corneal flap was created, lifted, and the interface and stroma inoculated with M. chelonae. Eyes were randomized to one of three groups, as follows: 0.3% gatifloxacin, 0.3% ciprofloxacin or control. Treatment was initiated immediately after the surgery and applied 4 times a day for one week, then discontinued. After the final clinical examination at day 21, some globes were enucleated, and corneas harvested under sterilized conditions to be processed for microbiology, histopathologic analysis by standard light microscopy, and scanning electronic microscopy. Results: At day 21, 100% of controls, 60% of the ciprofloxacin group and 10% of gatifloxacin had infection. (P < .05). Conclusions: Gatifloxacin demonstrated an improved activity towards atypical mycobacteria keratitis prevention compared to ciprofloxacin.

Keywords: antibiotics/antifungals/antiparasitics • keratitis • bacterial disease