May 2004
Volume 45, Issue 13
ARVO Annual Meeting Abstract  |   May 2004
Methicillin Resistant Staphyloccus Aureus (MRSA) is sensitive to Moxifloxacin
Author Affiliations & Notes
  • R.A. Eiferman
    Ophthalmology, University of Louisville, Louisville, KY
  • Footnotes
    Commercial Relationships  R.A. Eiferman, Alcon Laboratories F.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4915. doi:
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    • Get Citation

      R.A. Eiferman; Methicillin Resistant Staphyloccus Aureus (MRSA) is sensitive to Moxifloxacin . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4915.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose:: To determine whether Methicillin Resistant Staphylococcus aureus (MRSA) is sensitive to Vigamox (moxifloxacin 0.5%), a new fourth generation topical fluoroquinolone antibiotic Methods:10 clinical isolates and one ATCC strain of MRSA were utilized. A 0.5 McFarland standard 1 x 108 CFU/ml was prepared from fresh 18–24 hour cultures. Serial ten–fold dilutions of commercially available moxifloxacin was prepared in Mueller Hinton Broth. Within 15 minutes after the inoculum has been standardized, 1 ml was added to each tube. The final organism concentration in each tube was 1 x 105 CFU/ml. The inoculated tubes were incubated at 35 0C for 16–20 hours in an ambient air incubator. Results:There was 100% kill of all 11 strains of MRSA. Conclusions:While MRSA is not sensitive to moxifloxacin at levels achieved in serum, 100% kill was achieved with commercially available topical moxifloxacin

Keywords: antibiotics/antifungals/antiparasitics • microbial pathogenesis: experimental studies • bacterial disease 

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