Abstract
Abstract: :
Purpose: To evaluate the penetration of gatifloxacin ophthalmic solution 0.3% (Zymar TM, Allergan, Inc.) into the aqueous humor of patients undergoing standard cataract surgery. Methods: This single center, open–label clinical study determined the concentration of gatifloxacin in the aqueous humor of 10 patients who underwent a dosing regimen of gatifloxacin 0.3% prior to cataract surgery. These patients instilled gatifloxacin 0.3% in the eye to receive surgery at a dosing regimen of 1 drop 4 times/day for 2 days, and then 1 drop every 10 minutes for 1 hour on the day of surgery. Anterior chamber fluid was withdrawn during surgery with a 30–gauge cannula, and the gatifloxacin concentration was quantified by HPLC. Results: The mean concentration (± SD) of gatifloxacin in aqueous humor was 1.26 ± 0.55 mcg/mL. Conclusions: Gatifloxacin ophthalmic solution 0.3% showed good penetration into the aqueous of patients at the time of cataract surgery. The mean aqueous humor concentration of gatifloxacin achieved in this study meets or exceeds previously published minimal inhibitory concentration values for gatifloxacin against commonly found bacterial ocular pathogens, including species of Staphylococcus and Streptococcus.
Keywords: antibiotics/antifungals/antiparasitics • bacterial disease • conjunctivitis