May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Corneal Concentrations of Moxifloxacin following Topical Administration in a Rabbit Model
Author Affiliations & Notes
  • R. Mather
    Ophthalmology, Ivey Eye Institute,University of Western Ontario, London, ON, Canada
  • J.M. Stewart
    Ophthalmology, University of California, San Francisco, San Francisco, CA
  • T. Prabriputaloong
    Ophthalmology, Francis I Proctor Foundation, San Francisco, CA
  • J. Wong
    Ophthalmology, University of California, San Francisco, San Francisco, CA
  • S.D. McLeod
    Ophthalmology, University of California, San Francisco, San Francisco, CA
  • Footnotes
    Commercial Relationships  R. Mather, None; J.M. Stewart, None; T. Prabriputaloong, None; J. Wong, None; S.D. McLeod, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 4989. doi:
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    • Get Citation

      R. Mather, J.M. Stewart, T. Prabriputaloong, J. Wong, S.D. McLeod; Corneal Concentrations of Moxifloxacin following Topical Administration in a Rabbit Model . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4989.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To investigate the corneal concentrations of topically applied moxifloxacin using a novel dosing regimen. Methods: A prospective laboratory intervention design using a rabbit model to evaluate corneal concentrations of topically–administered moxifloxacin. One drop of topical 0.5% moxifloxacin was administered at times 0, 5, 10 minutes and again at 60, 65 and 70 minutes. Following the last application of moxifloxacin, corneal tissue was sampled 30, 60 and 120 minutes later. Moxifloxacin concentrations were determined by High Pressure Liquid Chromatography. The geometric mean tissue concentrations obtained in rabbit corneas are reported here and compared to the Minimum Inhibitory Concentration values for S. aureus and S. epidermidis. Results: Moxifloxacin concentrations in the rabbit cornea were 129.91, 158.66. and 47.6 µg/ml at 30, 60 and 120 minutes post dosing, respectively. The concentrations are at least 700–fold higher than the reported MIC values for fluoroquinolone–susceptible S. aureus and S. epidermidis and at least 19–fold higher than the reported MIC values for fluoroquinolone–resistant S. aureus and S. epidermidis, even at 120 minutes post–administration. Conclusions: A three–drop loading dose of topical moxifloxacin applied to the cornea every hour for a total of 2 hours may produce corneal concentrations that are many times higher than the MIC values for the common organisms responsible for bacterial keratitis.

Keywords: antibiotics/antifungals/antiparasitics • keratitis • cornea: clinical science 
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