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A.J. Roman, T.S. Aleman, A.V. Cideciyan, J.D. Chico, S.B. Schwartz, E.A. M. Windsor, E.E. Smilko, M.G. Maguire, S.G. Jacobson; Full–field light stimuli to test perception in severe retinal degenerations . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5099.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To develop a visual psychophysical outcome measure for severe retinal degenerative diseases. Methods:Modifications were made to a commercially–available automated perimeter to enable the instrument to deliver full–field stimuli (200 msec duration) for testing light sensitivity under dark adapted conditions; a test protocol was established. Patients with different types and severities of retinal degeneration (n=130) and normal subjects underwent dark adapted testing using white, red and blue full–field stimuli. For comparison with the full–field results, two–color dark adapted static perimetry was also performed. Results:There was sufficient dynamic range of the FST (full–field stimulus test) using white stimuli to quantify sensitivity in all patients studied and the length of testing was about 8 minutes per eye. FST levels showed predictable relationships with results from dark adapted perimetry. The determination of rod– or cone–mediation with chromatic stimuli in the FST related well to the mediation at the most sensitive retinal locations, as determined with two–color dark adapted perimetry. Conclusions:FST is a suitable candidate psychophysical outcome measure for treatment trials in severe retinal degenerations, considering the stimulus dynamic range, lack of fixation requirement, minimal modification of widely available equipment, simplicity of implementation and operation, and speed of procedure.
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