May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Full–field light stimuli to test perception in severe retinal degenerations
Author Affiliations & Notes
  • A.J. Roman
    Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA
  • T.S. Aleman
    Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA
  • A.V. Cideciyan
    Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA
  • J.D. Chico
    Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA
  • S.B. Schwartz
    Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA
  • E.A. M. Windsor
    Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA
  • E.E. Smilko
    Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA
  • M.G. Maguire
    Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA
  • S.G. Jacobson
    Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA
  • Footnotes
    Commercial Relationships  A.J. Roman, None; T.S. Aleman, None; A.V. Cideciyan, None; J.D. Chico, None; S.B. Schwartz, None; E.A.M. Windsor, None; E.E. Smilko, None; M.G. Maguire, None; S.G. Jacobson, None.
  • Footnotes
    Support  NIH/NEI EY–13729, EY–13385; Foundation Fighting Blindness, Macula Vision Research Foundation
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 5099. doi:
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      A.J. Roman, T.S. Aleman, A.V. Cideciyan, J.D. Chico, S.B. Schwartz, E.A. M. Windsor, E.E. Smilko, M.G. Maguire, S.G. Jacobson; Full–field light stimuli to test perception in severe retinal degenerations . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5099.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:To develop a visual psychophysical outcome measure for severe retinal degenerative diseases. Methods:Modifications were made to a commercially–available automated perimeter to enable the instrument to deliver full–field stimuli (200 msec duration) for testing light sensitivity under dark adapted conditions; a test protocol was established. Patients with different types and severities of retinal degeneration (n=130) and normal subjects underwent dark adapted testing using white, red and blue full–field stimuli. For comparison with the full–field results, two–color dark adapted static perimetry was also performed. Results:There was sufficient dynamic range of the FST (full–field stimulus test) using white stimuli to quantify sensitivity in all patients studied and the length of testing was about 8 minutes per eye. FST levels showed predictable relationships with results from dark adapted perimetry. The determination of rod– or cone–mediation with chromatic stimuli in the FST related well to the mediation at the most sensitive retinal locations, as determined with two–color dark adapted perimetry. Conclusions:FST is a suitable candidate psychophysical outcome measure for treatment trials in severe retinal degenerations, considering the stimulus dynamic range, lack of fixation requirement, minimal modification of widely available equipment, simplicity of implementation and operation, and speed of procedure.

Keywords: retinal degenerations: hereditary • clinical (human) or epidemiologic studies: systems/equipment/techniques 
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