May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Ultraestructure Of Nevus Of Ota Whit Choroideal Melanoma
G.R. Piantoni; D.E. Pelayes; D. Colombero; C.H. Pastore; N. Lago; F. Contreras; J.O. Zarate
Author Affiliations & Notes
  • G.R. Piantoni
    Ophthalmology, Hospital Carlos G Durand, Faculty of Medicine, University of Buenos Aires, Argentina
    Pathology, LIOCiV Laboratory of Ophthalmic Investigation and Visual Science, Faculty of Medicine, University of Buenos Aires, Argentina
  • D.E. Pelayes
    Ophthalmology, Hospital Carlos G Durand, Faculty of Medicine, University of Buenos Aires, Argentina
    Pathology, LIOCiV Laboratory of Ophthalmic Investigation and Visual Science, Faculty of Medicine, University of Buenos Aires, Argentina
  • D. Colombero
    Ophthalmology, Hospital Carlos G Durand, Faculty of Medicine, University of Buenos Aires, Argentina
  • C.H. Pastore
    Ophthalmology, Hospital Carlos G Durand, Faculty of Medicine, University of Buenos Aires, Argentina
  • N. Lago
    Pathology, LIOCiV Laboratory of Ophthalmic Investigation and Visual Science, Faculty of Medicine, University of Buenos Aires, Argentina
    Pathology, Faculty of Medicine, University of Buenos Aires, Argentina
  • F. Contreras
    INO, Institute of Ophthalmology, Lima, Peru
  • J.O. Zarate
    Pathology, LIOCiV Laboratory of Ophthalmic Investigation and Visual Science, Faculty of Medicine, University of Buenos Aires, Argentina
    Pathology, Faculty of Medicine, University of Buenos Aires, Argentina
  • Footnotes
    Commercial Relationships  G.R. Piantoni, None; D.E. Pelayes, None; D. Colombero, None; C.H. Pastore, None; N. Lago, None; F. Contreras, None; J.O. Zarate, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 5204. doi:
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      G.R. Piantoni, D.E. Pelayes, D. Colombero, C.H. Pastore, N. Lago, F. Contreras, J.O. Zarate; Ultraestructure Of Nevus Of Ota Whit Choroideal Melanoma . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5204.

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Abstract

Abstract: : Purpose: To present three cases of nevus of Ota in a hispanic population and their relation to choroidal melanoma, with histological and ultrastructural analysis. Methods: Three enucleated eyes were evaluated with hematoxylin–eosin and Masson trichrome staining, immunohistochemistry (Prot S100, HMB 45, Melan A)and transmission electron microscopy. The cytologic differences in the transition area between melanocytosis and melanoma were analyzed. Results:Melanocytes in melanocytosis had small oval body and a protruding nucleus with nucleoli and numerous cytoplasmic prolongations. The cytoplasm had moderate number of mitochondrias, smooth and rough endoplasmic reticulum and free ribosomes. Melanine granules were identified within the cytoplasm at several stages of development, including premelanosomes, melanosomes and myelinized granules with an approximate 0.05 micron diameter. Atypical cells showed an altered nuclear morphology with membrane irregularities and lack of organellas. Conclusions: Our case series showed atypical sectors of melanoma within typical ones (melanocytosis). We have not found any previous electron microscopy report of choroidal melanoma in nevus of Ota in the hispanic population.

Keywords: oncology • melanoma • microscopy: electron microscopy 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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