May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Efficacy of intravitreal tissue plasminogen activator injection for central retinal vein occlusion with cystoid macular edema
H. Ohashi; H. Takagi; H. Nishiwaki; K. Miyamoto; H. Oh; T. Murakami; Y. Honda
Author Affiliations & Notes
  • H. Ohashi
    Ophthal & Vis Science, Kyoto University, Sakyo–ku, Japan
  • H. Takagi
    Ophthal & Vis Science, Kyoto University, Sakyo–ku, Japan
  • H. Nishiwaki
    Ophthal & Vis Science, Kyoto University, Sakyo–ku, Japan
  • K. Miyamoto
    Ophthal & Vis Science, Kyoto University, Sakyo–ku, Japan
  • H. Oh
    Ophthal & Vis Science, Kyoto University, Sakyo–ku, Japan
  • T. Murakami
    Ophthal & Vis Science, Kyoto University, Sakyo–ku, Japan
  • Y. Honda
    Ophthal & Vis Science, Kyoto University, Sakyo–ku, Japan
  • Footnotes
    Commercial Relationships  H. Ohashi, None; H. Takagi, None; H. Nishiwaki, None; K. Miyamoto, None; H. Oh, None; T. Murakami, None; Y. Honda, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 5224. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Efficacy of intravitreal tissue plasminogen activator injection for central retinal vein occlusion with cystoid macular edema
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      H. Ohashi, H. Takagi, H. Nishiwaki, K. Miyamoto, H. Oh, T. Murakami, Y. Honda; Efficacy of intravitreal tissue plasminogen activator injection for central retinal vein occlusion with cystoid macular edema . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5224.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Abstract: : Purpose:To investigate the efficacy of intravitreal tissue plasminogen activator (tPA) injection for cystoid macular edema (CME) associated with central retinal vein occlusion (CRVO). Methods:Nineteen eyes of patients presenting with CRVO with severe CME were treated with intravitreal tPA (Monteplase, 40k International Unit) injection with 6 months of follow–up. Mean age was 66.2 years old and 11 were female. Baseline and post–operative follow–up examinations included visual acuity, fluorescein angiography, and detailed imaging of macular edema by optical coherence tomography (OCT). Mean follow–up period was 14.3 months and mean duration from onset of CRVO to tPA injection was 1.4 months. Results:At the end of follow–up, mean macular thickness decreased from 887 to 209 (p < 0.001) µm and mean logMAR visual acuity improved from 1.14 to 0.638 (p<0.001). There was significant correlation between reduction of macular thickness and increase in visual acuity. Posterior vitreous detachment (PVD) was not observed pre–operatively in 16 eyes. Nine eyes (56%) out of 16 eyes showed PVD post–operatively. Eyes induced PVD post–operatively archived significantly more reduction of macular thickness compared to eyes without PVD (p<0.05). The duration from onset of CRVO to surgery significantly correlated with the macular thickness at the final visit (p<0.05). In contrast, logMAR visual acuity did not significant correlation with the duration. Mean retinal transit time was significantly decreased from 4.61 to 3.90 seconds (p<0.05). Recurrences and complications were not observed. Conclusions:Intravitreal tPA injection is an effective treatment for CME and impaired visual acuity associated with CRVO. The mechanism of its efficacy includes multiple factor such as PVD and improvement of circulation. None.

Keywords: vitreoretinal surgery • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • macula/fovea 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept