May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Normal human posterior pole retinal thickness measured with the Retinal Thickness Analyzer
F. Knezevich; H.D. Jampel; Y. Ding; H. Quigley; C. Marks; D. Friedman; N. Congdon; S. Vitale; R. Zeimer
Author Affiliations & Notes
  • F. Knezevich
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • H.D. Jampel
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Y. Ding
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • H. Quigley
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • C. Marks
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • D. Friedman
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • N. Congdon
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • S. Vitale
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
    Division of Epidemiology and Clinical Research, National Eye Institute, Bethesda, MD
  • R. Zeimer
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Footnotes
    Commercial Relationships  F. Knezevich, None; H.D. Jampel, None; Y. Ding, None; H. Quigley, None; C. Marks, None; D. Friedman, None; N. Congdon, None; S. Vitale, None; R. Zeimer, Talia Technologies, Inc. P.
  • Footnotes
    Support  NIH grant EY R01–12295
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 5251. doi:
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      F. Knezevich, H.D. Jampel, Y. Ding, H. Quigley, C. Marks, D. Friedman, N. Congdon, S. Vitale, R. Zeimer; Normal human posterior pole retinal thickness measured with the Retinal Thickness Analyzer . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5251.

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Abstract

Abstract: : Purpose:Retinal ganglion cells and their nerve fibers are lost in glaucoma. This loss of tissue can be measured in the posterior pole by assessing retinal thickness (RT). However, characterization of normal RT in older individuals is important to facilitate comparison with glaucomatous eyes. Methods:We studied RT of 98 normal eyes of 52 individuals recruited from a population–based survey of eye disease (the Baltimore Eye Survey) and from hospital employees and volunteers. A glaucoma specialist examined all participants and those with macular degeneration, diabetic retinopathy, optic nerves suspicious for glaucoma, SITA Fast visual field testing results that could be compatible with glaucoma, or visual acuity worse than 20/40 were excluded. A 1999 version of the Retinal Thickness Analyzer (Talia Technologies, Neve Ilan, Israel) was used to scan a 6 x 6 mm2 area of the posterior pole, centered on the fovea, obtaining parallel optical cross–sections 200 µm apart. We used an automated algorithm (version 4.10) to generate RT maps, and a custom Matlab program to generate RT summary parameters for the superior and inferior hemispheres and the perifoveal annuli (area corresponding to the stacked ganglion cell layer surrounding the fovea). Mean RT was computed for each region. We excluded regions in which < 75% of points were measurable. Results:Participants were 48–80 years old (mean, 61 years); 38 (73%) were female. There were 46 persons of European descent, 9 of African–American descent, and 3 of Asian descent. RT variability was similar over the macular map. A decrease in RT was found with age (slope= 4.5 µm per 10 years, p= 0.08). RT was similar for males and females (159.1 and 167.8 µm, p= 0.2). Superior and inferior RT were similar. As expected, perifoveal annulus RT was greater than entire hemisphere RT, for both the superior and inferior regions. Retinal Thickness in normal eyes (n=98) 

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Conclusions: These findings will allow better assessment of RT loss in glaucomatous eyes, as other normal RT databases lack information on older individuals.

Keywords: clinical (human) or epidemiologic studies: natural history • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retina 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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