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N. Nagai, S. Ishida, K. Shinoda, Y. Imamura, K. Noda, M. Inoue; Surgical effect and complications of indocyanine green–assisted internal limiting membrane peeling for idiopathic macular hole . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5272.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To compare the surgical outcome for idiopathic macular hole with or without indocyanine green (ICG) staining during vitrectomy combined with internal limiting membrane (ILM) peeling. Methods: Thirty–five eyes of 31 patients who underwent ICG–assisted ILM peeling during macular hole surgery (a staining group) were compared with 18 eyes of 16 patients who underwent ILM peeling without ICG staining (a non–staining group). Anatomical closure, visual improvement and postoperative complications were evaluated in each group. Results: Macular holes were closed following initial surgery in 97% of the staining group and 94% of the non–staining group. Eyes with postoperative logMAR visual acuity (logMAR VA) better than 0.1 were significantly fewer in the staining group (14%) than in the non–staining group (38%, p<0.05). Anatomical postoperative complications occurred in 31% of the staining group and 11% of the non–staining group. Phototoxic damage of retinal pigment epithelium and retinoschisis were specific to the staining group. Functional complications were observed only in the staining group. Conclusions:There was no statistical difference in anatomical closure depending on the intraoperative use of ICG. However, ICG–assisted surgery might limit the visual improvement better than 0.1 (logMAR). ICG application during macular hole surgery combined with ILM peeling should be reconsidered.
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