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R.D. Fechtner, J.M. Liebmann, M. Fingeret, E. Buroff, P.J. Lama, S. Zafar, R. Ritch; Reproducibility of retinal nerve fiber layer measurements using a scanning laser polarimeter with variable corneal compensation . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5505.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To assess the reproducibility of RNFL measurements in normal and glaucomatous eyes using a scanning laser polarimeter incorporating individualized corneal compensation. Methods: Twenty–five eyes of glaucoma patients and 27 eyes of normal volunteer were imaged three times each to determine short–term reproducibility of RNFL measurements. Measurements were performed using a scanning laser polarimeter (SLP) incorporating individualized variable corneal compensation (GDx–VCCTM, Laser Diagnostic Technologies, Inc., San Diego, CA). The variable corneal compensation algorithm was applied prior to obtaining each image. The standard deviation for each pixel was calculated from the three scans and averaged over the entire eye to give a mean sd value per patient. Reproducibility was defined as average of the mean standard deviation of pixels (excluding the region of the optic nerve) for the entire field, and the coefficient of variation for the parameters generated by the GDX–VCC software. Results: The mean standard deviation of the thickness map was 3.6 ± 1.0 for normals and 4.2 ± 1.1 for the glaucoma patients. Conclusion: Reproducibility of pixels was similar for normal and glaucomatous eyes. Reproducibility of calculated parameters was somewhat better in normal than glaucomatous eyes.The reproducibility for SLP with variable corneal compensation exceeds that reported for SLP with fixed corneal compensation. Coefficients of Variation
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