May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Ftal ocular volumetric study by magnetic resonance imaging in pregnant woman
Author Affiliations & Notes
  • C. Fogliarini
    Ophtalmologie,
    CHU Nord, Marseille, France
  • N. Girard
    Radio imagerie,
    CHU Nord, Marseille, France
  • D. Denis
    Ophtalmologie,
    CHU Nord, Marseille, France
  • H. Chaudet
    Biostatistique,
    CHU Nord, Marseille, France
  • M. Panuel
    Radio imagerie,
    CHU Nord, Marseille, France
  • Footnotes
    Commercial Relationships  C. Fogliarini, None; N. Girard, None; D. Denis, None; H. Chaudet, None; M. Panuel, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 5532. doi:
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    • Get Citation

      C. Fogliarini, N. Girard, D. Denis, H. Chaudet, M. Panuel; Ftal ocular volumetric study by magnetic resonance imaging in pregnant woman . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5532.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: presentation of a technique allowed to calculate the foetal ocular volume by resonance magnetic imagery in pregnant woman. We report the results found in a preliminary study of 40 foetuses Methods: prospective study of 40 foetal MRI brain scans. Gestational age ranged from 24 to 38 weeks amenorrhea. They did not present ocular or brain anomalies. Volume was computed from the "TRUFISP 3D" acquisition program, which divided each ocular globe into a succession of small overlapping frontal plane slices. Ocular globe surface was evaluated on each slice by a threshold computer method and a partial volume was extrapolated from slice thickness. The sum of partial volumes allows calculation of the total ocular globe volume Results:the computed volumes ranged from 563 to 2400 mm³. Statistical analysis showed a strong correlation (r = 0.8476 with p<10 –4) between ocular volume and gestational age. Regression analysis showed the relationship between ocular volume and gestational age to be a straight line equation Conclusions: this is the first study concerning measurement of ocular foetal volume in vivo. Ocular volume changes with gestational age, and growth is maximal during the last trimester of pregnancy. A possible application of this study is to determine normal foetal ocular volume correlated with gestational age for helping in diagnosis of buphtalmia (synonymous of congenital glaucoma), allowing prenatal diagnosis therefore early management

Keywords: anatomy • clinical (human) or epidemiologic studies: biostatistics/epidemiology methodology • imaging/image analysis: clinical 
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