The pressure lowering effect of combined therapy with latanoprost 0.005% and bimatoprost 0.03%.

Abstract

Abstract: : Purpose: To compare the intraocular pressure lowering effect of combination therapy with latanoprost 0.005% and bimatoprost 0.03%. Methods:Thirty–one patients with glaucoma or ocular hypertension currently using either latanoprost 0.005% or bimatoprost 0.03% in one or both eyes were treated with combined therapy (latanoprost 0.005% and bimatoprost 0.03%) in one eye. The eye with a higher intraocular pressure (IOP) at the screening visit was chosen as the study eye; if the IOP was equal, one eye was selected by the investigator. The previous medication was instilled in the evening, and the study medication was administered in the morning by the patient. The morning and afternoon intraocular pressures were measured in the study eye on Day 1 (baseline) and Day 15 of combined treatment. One intraocular pressure was also measured on Day 7 of combined therapy for safety monitoring. Results:The average patient age was 61.35 ± 12.0 years (range 36–89). Fifteen men and sixteen women with primary open–angle glaucoma (68%), pseudoexfoliation glaucoma (3%), pigmentary glaucoma (6%), and ocular hypertension (23%) comprised the study population. The average baseline (Day 1) mean intraocular pressures in morning and afternoon were 18.66 ± 3.72 mmHg and 17.41 ± 3.8 mmHg. Average IOP measurements (AM and PM) after 15 days of combination therapy were 18.96 ± 3.48 mmHg and 18.13 ± 3.72 mmHg. No significant differences between Day 1 and Day 15 intraocular pressures were identified [P=0.56 (AM), P=0.12 (PM)]. Seven patients (23%) had a 2 mmHg or greater decrease in intraocular pressure with combination therapy; three patients had a decrease in AM IOP and four patients a decrease in PM IOP. Thirteen patients (42%) had a rise in IOP greater than 2 mmHg; five patients with a rise in AM IOP, six patients with a rise in PM IOP, and two patients with an increase in both AM and PM measurements of IOP. Seven patients reported redness, irritation, and lid burning with combined therapy. Symptoms resolved in five patients by study Day 15. Conclusions: Combination topical therapy with latanoprost 0.005% and bimatoprost 0.03% had no clinically significant additive effect on lowering the intraocular pressure in thirty–one patients receiving combination therapy for fifteen days. This combination of topical therapy may increase the intraocular pressure in some patients.

Keywords: intraocular pressure • pharmacology • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials