May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Digital planimetric evaluation of peripapillary atrophy in normal and glaucomatous eyes.
Author Affiliations & Notes
  • I. Bourtsoukli
    Optometry & Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • I.A. Cunliffe
    Opthalmology, Birmingham Heartlands Hospital, Birmingham, United Kingdom
  • R.J. Kumar
    Ophthalmology, University of Wales College of Medicine, Cardiff, United Kingdom
  • E.A. Ansari
    Ophthalmology, University of Wales College of Medicine, Cardiff, United Kingdom
  • R.V. North
    Optometry & Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • J.M. Wild
    Optometry & Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • J.E. Morgan
    Ophthalmology, University of Wales College of Medicine, Cardiff, United Kingdom
  • Footnotes
    Commercial Relationships  I. Bourtsoukli, None; I.A. Cunliffe, None; R.J. Kumar, None; E.A. Ansari, None; R.V. North, None; J.M. Wild, None; J.E. Morgan, Haag–Streit P.
  • Footnotes
    Support  WORD, NERC UK
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 5561. doi:
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      I. Bourtsoukli, I.A. Cunliffe, R.J. Kumar, E.A. Ansari, R.V. North, J.M. Wild, J.E. Morgan; Digital planimetric evaluation of peripapillary atrophy in normal and glaucomatous eyes. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):5561.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To investigate the relationship between glaucomatous optic nerve head damage and the extent of peripapillary atrophy (PPA), as assessed by multiple, experienced observers. Methods: Optic disc images from 43 control subjects (mean age 59.2 years, SD 10.5 years) and 117 patients with early–moderate open angle glaucoma (mean age 65.5 years, SD 10.3) were digitised and analysed by digital stereoscopic planimetry. Patient diagnosis was based on analysis of the optic disc and visual field. Optic disc analysis was performed by 3 ophthalmlologists trained to fellowship standard in glaucoma who were masked to patient diagnosis. Stereoscopic images were viewed using a Z screen (Stereographics Corp.) with quad buffered display (24 bits per pixel true color). Custom cursors enabled neuroretinal rim measurements at the level of the scleral rim. Peripapillary α and ß zone atrophy was measured at 10 degree intervals around the disc. Images were scaled to compensate for camera–eye magnification effects. Results:The group mean planimetry results and mean global visual field indices are shown. There was considerable interobserver variation in the assessment of PPA. Although there was a trend for α and ß zone atrophy to increase in glaucoma this did not reach statistical significance. Multivariate analysis with disc and rim area, age, MD ,PSD and diagnosis indicated PSD as an explanatory variable for PPA α (P=0.005) and rim area for PPA ß (P=0.001).  

Conclusions: Considerable interobserver variation was noted in the assessment of PPA in both normal and glaucomatous eyes. Further work is required before PPA estimates can be used as reliable indicators of glaucomatous optic nerve head damage in the clinical setting.

Keywords: imaging/image analysis: clinical • optic disc 
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