Effects of Latanoprost 0.005% and Timolol 0.5% Gel-forming Solution on Diurnal Intraocular Pressure Curve in Japanese Normal-tension Glaucoma

Abstract

Abstract: : Purpose: To prospectively compare the effect of latanoprost 0.005% and timolol 0.5% gel-forming solution on the diurnal intraocular pressure. Methods: Thirty eyes of 30 normal-tension glaucoma patients were enrolled (12 men and 18 women; mean age 53.7±14.6 years). After four-week wash-out of glaucoma medication, patients were randomly assigned to treat either with latanoprost 0.005% once daily or timolol 0.5% gel-forming solution once daily. Diurnal IOP was measured every two hours by one investigator with the same Goldmann applanation tonometer on day 0 without medication, on day 2 with medication. Ocular hypotensive effect was analyzed regarding IOP, DIOP (without medication – with medication) and the area under the curve (AUC). The AUC was divided into daytime (from 6 a.m. to 6 p.m.) and nighttime (from 6 p.m. to 6 a.m.). Results: The mean diurnal IOP without medication were 12.6 ± 1.9 mmHg in the Latanoprost group and 12.8 ± 1.9 mmHg in the Timorlol group (mean ± SD). The Latanoprost group showed significant IOP-lowering effect throughout 24 hours (DIOP; 1.4~2.2mmHg). On the other hand, the timolol group did not show significant IOP-lowering effect during nighttime (0~6 a.m.). The Latanoprost group showed no difference between daytime AUC and nighttime AUC. The daytime AUC was significantly larger than the nighttime AUC in the Timolol group. Conclusion: Both latanoprost 0.005% and timolol 0.5% gel-forming solution had significant ocular hypotensive effect in Japanese normal-tension glaucoma patients. Latanoprost 0.005% showed significant IOP-lowering effect throughout 24 hours. Ocular hypotensive effect of nighttime of timolol 0.5% gel-forming solution was less than that of daytime. CR: None

Keywords: intraocular pressure • drug toxicity/drug effects • outflow: trabecular meshwork