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K.M. Goins, D. Kiernan, L. Farrokh-Siar; Posterior Capsular Opacification (PCO) After Phacoemulsification in Rabbits Using Rigid and Flexible Haptic Acrylic Lenses and Intracameral Minoxidil . Invest. Ophthalmol. Vis. Sci. 2003;44(13):281.
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Purpose:Minoxidil, a known inhibitor of lens epithelial cell (LEC) proliferation at concentrations of 2 mM and above in rabbit and human cell culture experiments, was used during phacoemulsfication in rabbits to determine if the incidence of PCO could be reduced. Methods:Twenty consecutive New Zealand albino rabbits were randomized to receive intracameral Minoxidil (4 mM for 10 minutes) or placebo after phacoemulsification with posterior chamber lens implantation. Ten eyes received a rigid three piece acrylic lens (Alcon MA30BA, 5.5 mm optic), while ten additional eyes received a flexible single piece acrylic lens (Alcon SA30AL, 5.5 mm optic). PCO was graded in three separate areas using direct and retroillumination slit lamp photography (zones 0-3 mm, 3-6 mm, and 6-10 mm). PCO in each zone was graded by severity (0=none, 1=minimal, 2=mild, 3=moderate, and 4=severe). The maximum PCO score attainable was 12. PCO was assessed at 1 and 6 months after surgery. Results:Preliminary results show that Minoxidil caused a clinically significant decrease in PCO scores at one month in both acrylic lens groups (3.5 treatment vs 5.0 control). However, at six months after surgery, control and treatment groups exhibited moderate to severe PCO with the SA30AL flexible acrylic lens group in particular displaying more severe PCO and IOL displacement (PCO score 8.5 treatment vs 9.5 control). The MA30BA rigid acrylic lens group had less severe central PCO and IOL displacement in general. Conclusions: One month after phacoemulsification, intracameral minoxidil has a small but clinically beneficial effect on PCO development regardless of acrylic lens design. After month, however, the rigid design of the MA30BA lens seemed to play a more important role in reducing central PCO and late IOL displacement. This research is beneficial because it suggests that eyes which are subject to severe inflammation after cataract surgery (i.e. uveitis and children), may benefit from using a rigid acrylic lens design to reduce the incidence of PCO and late IOL decentration from excessive Soemmering's ring development.
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