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H. Yanagawa, S. Kobayakawa, Y. Katayama, K. Nagamine, M. Miura, T. Tochikubo; Changes in Lens Epithelial Cell Migration for Different Edge Design after Silicone Intraocular Lens Implantation . Invest. Ophthalmol. Vis. Sci. 2003;44(13):286.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To compare the changes in lens epithelial cells(LECs) migration for different optic edge design after implantation of silicone intraocular lenses(IOLs) in rabbits. Methods: Japanese albino rabbits (n=32) were used. Two types of silicone IOLs (Canonstaar) were prepared: one was AQ2013 with rounded edges (RE) and the other was AQ310NV with sharp edges (SE). After phacoemulsification under general anesthesia, IOLs were implanted in 16 eyes for each type. Four eyes were enucleated for each week postoperatively. Histopathological examinations were performed. Results: One week postoperatively, posterior capsule was in contact with the IOL optic edge and the migration of LECs on the posterior capsule was not recognized in all eyes. Especially in the RE group, the lens capsule wrapped around IOL optic edges tightly in all eyes. Two weeks postoperatively, the migration of LECs was recognized even in the eye that the posterior capsule was in contact with the IOL optic edges in the RE group. On the other hand, the migration was inhibited in the eye that the posterior capsule was in contact with IOL edge in the SE group. Conclusion: The contact of posterior capsule to IOL optic edge was essential for the inhibition of the migration of LECs on the posterior capsule. It was suggested that the contact with optic edge was formed earlier in a rounded edge than in a sharp edge. However, it was found that a rounded edge could not prevent the migration. The contact pressure of a sharp optic edge seems to play a role in preventing the posterior capsule opacification.
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