The Effect of Edge and Haptic Design on Posterior Capsule Opacification in Silicone Intraocular Lens

Abstract

Abstract: : Purpose: To compare with posterior capsule opacification (PCO) for different edge and haptic design of silicone intraocular lenses(IOLs) in rabbits. Methods: Japanese albino rabbits (n=32) were used. Four types of IOLs (Canonstaar, Japan) were prepared: AQ2013V of three-piece IOL with rounded edge (3PRE), AQ310NV of 3p with sharp edge (3PSE), AA4203F of 1p plate-haptic IOL with rounded edge (1PRE) and Canonstaar Japan original IOL of 1p with sharp edge (1PSE). After phacoemulsification under general anesthesia, IOLs were implanted for each type. Three weeks postoperatively, enucleated eyes were observed and photographed using the Miyake-Apple view. The percentage area of PCO was calculated using POCOman software. Then histopathological examinations were performed. Results: The mean percentage area of PCO was 43.8±24.5 (mean ± SD) in the 3PRE group (n=12), 25.6±24.6 in the 3PSE group (n=10) , 62.4±31.3 in the 1PRE group (n=12) and 30.2±27.3 in the 1PSE group (n=16). The PCO area in the 1PRE group was significantly greater than in the 3PSE and 1PSE group (p<0.05). And a tendency was noticed that PCO area of sharp edge IOL was smaller than rounded edge IOL. In histopathological findings, the migration of lens epithelial cells (LECs) was inhibited in the part with plate-haptic up to the capsular bag’s equator in the 1PRE and 1PSE group. And LECs of the 3PRE and 1PRE group migrated to the surface of posterior capsule. With the 3PSE and 1PSE group, LECs migration was inhibited in most eyes. Conclusions: The sharp edge and plate-haptic shape of silicone IOL seems to play a role in preventing LECs from migrating and forming PCO.

Keywords: posterior capsular opacification (PCO) • pathology: experimental • animal model