May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Different Acrylic Intraocular Lenses - Effect on Lens Epithelial Cells In vitro on Human Capsular Bags
Author Affiliations & Notes
  • A. Liekfeld
    Augenklinik Campus Virchow Klin, Charite, Berlin, Germany
  • N. Pahms
    Augenklinik Campus Virchow Klin, Charite, Berlin, Germany
  • N. Torun
    Augenklinik Campus Virchow Klin, Charite, Berlin, Germany
  • C. Hartmann
    Augenklinik Campus Virchow Klin, Charite, Berlin, Germany
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 289. doi:
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      A. Liekfeld, N. Pahms, N. Torun, C. Hartmann; Different Acrylic Intraocular Lenses - Effect on Lens Epithelial Cells In vitro on Human Capsular Bags . Invest. Ophthalmol. Vis. Sci. 2003;44(13):289.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To investigate the effect of different acrylic materials of one-piece foldable intraocular lenses (IOL)on lens epithelial cells (LEC)in vitro on human capsular bags. Methods: Sham cataract surgery, including anterior capsulorhexis, nucleus hydroexpression, and aspiration of lens fibers, was performed on 16 donor eyes(8 pairs)after removal of the cornea. In each pair one eye had a hydrophilic (AkreosFit, Bausch&Lomb;), the other eye had a hydrophobic (SA60AT, Alcon) acrylic one-piece IOL implanted. The capsular bag including the IOL was dissected free, pinned upside-down on a culture dish, covered with medium and incubated. It was documented how long it lasted until the posterior capsule was totally covered by a confluent monolayer of LEC. Results: Posterior capsule was totally covered by a confluent monolayer of LEC on average at day 12.4 (+/-2.8) in the capsular bags with a hydrophilic IOL, and at day 13 (+/-2.75) with a hydrophobic IOL. The difference ist not statistically significant. Conclusions: There seems to be a slight advantage for the hydrophobic acrylic one-piece IOL in terms of secondary cataract inhibition.

Keywords: posterior capsular opacification (PCO) • cataract • proliferation 
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