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A. Liekfeld, N. Pahms, N. Torun, C. Hartmann; Different Acrylic Intraocular Lenses - Effect on Lens Epithelial Cells In vitro on Human Capsular Bags . Invest. Ophthalmol. Vis. Sci. 2003;44(13):289.
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Purpose: To investigate the effect of different acrylic materials of one-piece foldable intraocular lenses (IOL)on lens epithelial cells (LEC)in vitro on human capsular bags. Methods: Sham cataract surgery, including anterior capsulorhexis, nucleus hydroexpression, and aspiration of lens fibers, was performed on 16 donor eyes(8 pairs)after removal of the cornea. In each pair one eye had a hydrophilic (AkreosFit, Bausch&Lomb;), the other eye had a hydrophobic (SA60AT, Alcon) acrylic one-piece IOL implanted. The capsular bag including the IOL was dissected free, pinned upside-down on a culture dish, covered with medium and incubated. It was documented how long it lasted until the posterior capsule was totally covered by a confluent monolayer of LEC. Results: Posterior capsule was totally covered by a confluent monolayer of LEC on average at day 12.4 (+/-2.8) in the capsular bags with a hydrophilic IOL, and at day 13 (+/-2.75) with a hydrophobic IOL. The difference ist not statistically significant. Conclusions: There seems to be a slight advantage for the hydrophobic acrylic one-piece IOL in terms of secondary cataract inhibition.
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