May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Perioptic Short Posterior Ciliary Artery and Central Retinal Artery Hemodynamics in Primary Open Angle Glaucoma Patients on Brimonidine
K.G. Schmidt; V. Klingmüller; A.G. Böhm; N.N. Osborne; L.E. Pillunat
Author Affiliations & Notes
  • K.G. Schmidt
    Ophthalmology, University of Dresden, Dresden, Germany
  • V. Klingmüller
    Radiology, University of Marburg, Marburg, Germany
  • A.G. Böhm
    Radiology, University of Marburg, Marburg, Germany
  • N.N. Osborne
    Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom
  • L.E. Pillunat
    Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom
  • Footnotes
    Commercial Relationships  K.G. Schmidt, None; V. Klingmüller, None; A.G. Böhm, None; N.N. Osborne, None; L.E. Pillunat, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 356. doi:
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      K.G. Schmidt, V. Klingmüller, A.G. Böhm, N.N. Osborne, L.E. Pillunat; Perioptic Short Posterior Ciliary Artery and Central Retinal Artery Hemodynamics in Primary Open Angle Glaucoma Patients on Brimonidine . Invest. Ophthalmol. Vis. Sci. 2003;44(13):356.

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Abstract

Abstract: : Purpose: Peripapillary hemodynamics is increasingly being discussed in the prognosis of primary open angle glaucoma (PAOG). Current antiglaucomatous drugs - in addition to reducing intraocular pressure (IOP) - should not impair perfusion to the optic nerve head, the area of primary damage in this progressive optic neuropathy. This study was designed to evaluate the influence of brimonidine, a potentially vasoconstrictive alpha-2-receptor agonist, on perioptic short posterior ciliary artery (PSPCA) and central retinal artery (CRA) vascular systems in POAG patients. Methods: The influence of brimonidine (0.2%), in standard dosage (BID, 1 eye) on PSPCA and CRA hemodynamics (9 MHz linear and phased array scanners, Elegra Advanced System, Siemens, Germany, transmission energy reduced to 40%, B-, C-, & triplex-modes), IOP, and systemic perfusion parameters was investigated in 17 POAG patients without clinically relevant extracranial stenosis (< 50% reduction in vessel diameter) as excluded by sonography of common, external and internal carotid arteries. Measurements were taken before and following 4 weeks of brimonidine therapy. Results (mean ± SD): Following application of brimonidine IOP (mmHg) in drug treated POAG eyes was significantly (sig., p< 0.0001) reduced from 26.4 ± 1.3 to 21.5 ± 1.6. When compared to pretreatment values PSPCA and CRA perfusion parameters (peak systolic velocity, enddiastolic velocity, pulsatility and resistance indexes and systemic perfusion parameters were not sig. (p> 0.05) altered following application of brimonidine. Conclusions: Brimonidine reduced IOP by 18.7%, a negative hemodynamic effect on vessels feeding the optic nerve head, the area of primary damage in POAG, was excluded by this study.

Keywords: blood supply • pharmacology • optic disc 
© 2003, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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