May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Ultrahigh Resolution Optical Coherence Tomography In Macular Dystrophy
M.G. Wirtitsch; E. Ergun; B. Hermann; A. Unterhuber; H. Sattmann; M. Stur; T. Ko; O. Findl; J.G. Fujimoto; W. Drexler
Author Affiliations & Notes
  • M.G. Wirtitsch
    Department of Ophthalmology, University of Vienna, Vienna, Austria
  • E. Ergun
    Department of Ophthalmology, University of Vienna, Vienna, Austria
  • B. Hermann
    Department of Medical Physics, University of Vienna, Vienna, Austria
  • A. Unterhuber
    Department of Medical Physics, University of Vienna, Vienna, Austria
  • H. Sattmann
    Department of Medical Physics, University of Vienna, Vienna, Austria
  • M. Stur
    Department of Medical Physics, University of Vienna, Vienna, Austria
  • T. Ko
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States
  • O. Findl
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States
  • J.G. Fujimoto
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States
  • W. Drexler
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States
  • Footnotes
    Commercial Relationships  M.G. Wirtitsch, None; E. Ergun, None; B. Hermann, None; A. Unterhuber, None; H. Sattmann, None; M. Stur, None; T. Ko, None; O. Findl, None; J.G. Fujimoto, CARL ZEISS Meditec, Inc P; W. Drexler, CARL ZEISS Meditec, Inc P.
  • Footnotes
    Support  FWF P14218-PSY, FWF Y159-PAT, CRAF-1999-70549, NIH-RO1-EY11289-14, NIH-RO1-CA75289-04
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 538. doi:
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      M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, H. Sattmann, M. Stur, T. Ko, O. Findl, J.G. Fujimoto, W. Drexler; Ultrahigh Resolution Optical Coherence Tomography In Macular Dystrophy . Invest. Ophthalmol. Vis. Sci. 2003;44(13):538.

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Abstract

Abstract: : Purpose: To examine and compare intraretinal changes in macular dystrophies with ultrahigh resolution optical coherence tomography (UHR-OCT) with reference to the intraretinal layers in the healthy macula. Methods: A compact, new generation UHR-OCT system has been developed and used in a clinical setting for the first time. 20 patients with Stargardt's disease (SD) (8 female and 12 male, mean age 35.8) and 20 patients with adult-onset foveomacular dystrophy (AOFVD) (10 female and 10 male, mean age 61.9) were imaged using UHR-OCT. Results: Patients with SD had a diffuse degenerative change with a reduction in all retinal layers, sub-pigmentepithelial deposits and focal loss of photoreceptors. Patients with AOFVD, on the other hand, had a normal retinal thickness, subretinal deposits and mostly intact photoreceptors. Conclusion: It has been demonstrated that UHR-OCT is a clinically feasible tool in examining and quantifying structural changes in hereditary macular dystrophy and therefore has the potential to contribute a better understanding of ocular pathogenesis.

Keywords: retina • retinal degenerations: hereditary • imaging/image analysis: clinical 
© 2003, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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