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K. Abe, H. Iijima, H. Hirakawa; Sensitivity in the Normally-Appearing Retina in Eyes With Moderately Advanced Retinitis Pigmentosa . Invest. Ophthalmol. Vis. Sci. 2003;44(13):541.
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Purpose: Eyes with moderately advanced retinitis pigmentosa (RP) generally show a central island of retina that preserves a normally-appearing dark red color in the macula. The present study investigates whether the normally-appearing retina in these eyes shows normal visual function measured with static perimetry. Methods: We studied 43 eyes of 22 patients with RP whose mean deviation of Humphrey central 10-2 perimetry was between -5 dB and -25 dB. The boundary line was determined and drawn between areas of the normally-appearing retina and of the degenerated retina on a fundus color picture of the subject eye. Then a table of total deviation values was superimposed onto the picture so that the value appears on the corresponding retinal area. For each eye, the mean and the standard deviation of the total deviation values were calculated for the fundus areas where the boundary line passes through. Results: The mean of the total deviation values on the boundary line ( ranging between -30.9 dB and -6.1 dB for all subject eyes ) were in the range between -20 dB and -10 dB for 70% of the subject eyes. The standard deviation of the values for each eye ranged between 1.4 dB and 10.3 dB. Conclusions: The boundary sensitivity that divides the normally-appearing retina and the apparently degenerated retina differed among eyes, which may reflect the diversity of the retinal pathology in eyes with RP.
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