Photodynamic Therapy for Choroidal Neovascularization in Ocular Histoplasmosis Syndrome

Abstract

Abstract: : Purpose: To study the results of photodynamic therapy (PDT) with verteporfin for choroidal neovascularization (CNV) secondary to ocular histoplasmosis syndrome (OHS). Methods: Clinical medical records including fluorescein angiograms and color photos of 56 eyes (52 patients) were retrospectively studied. The mean follow-up time(FUT) was 11.25 (3 to 30) months. Visual acuity (VA), recurrence of CNV and complications were investigated. Visual acuity changes by more than 2 Snellen lines was defined as improved or decreased, changes within 2 lines were defined as stabilized. Results: The changes of VA in different follow-up periods were : Repeated PDT treatments occurred: 2^nd PDT in 37eyes, 3^rd PDT in 16 eyes, 4^th PDT in 9 eyes, 5^th PDT in 2 eyes, and one eye has been treated 9 times. CNV recurred in 3 eyes, in 9 (2 eyes) and 15 months after last treatment. No obvious complication was observed during or post PDT treatment. Conclusion: Photodynamic therapy with verteporfin for choroidal neovascularization in OHS is an effective therapy offering the possibility of maintaining central vision in 70% to 80% of eyes. Supported by Crippled Children Vitreoretinal Research Foundation  

Keywords: choroid: neovascularization • photodynamic therapy • retinal neovascularization