May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Candida Infection as Factor Risk for Threshold ROP
D. Lepore; F. Molle; M.M. Pagliara; R. DeSantis; P.G. Matassa; G. Vento; F. Gallini; C. Romagnoli
Author Affiliations & Notes
  • D. Lepore
    Dept of Ophthalmology, Catholic University, Rome, Italy
  • F. Molle
    Dept of Ophthalmology, Catholic University, Rome, Italy
  • M.M. Pagliara
    Dept of Ophthalmology, Catholic University, Rome, Italy
  • R. DeSantis
    Dept of Ophthalmology, Catholic University, Rome, Italy
  • P.G. Matassa
    Nicu, Catholic University, Rome, Italy
  • G. Vento
    Nicu, Catholic University, Rome, Italy
  • F. Gallini
    Nicu, Catholic University, Rome, Italy
  • C. Romagnoli
    Nicu, Catholic University, Rome, Italy
  • Footnotes
    Commercial Relationships  D. Lepore, None; F. Molle, None; M.M. Pagliara, None; R. DeSantis, None; P.G. Matassa, None; G. Vento, None; F. Gallini, None; C. Romagnoli, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 592. doi:
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      D. Lepore, F. Molle, M.M. Pagliara, R. DeSantis, P.G. Matassa, G. Vento, F. Gallini, C. Romagnoli; Candida Infection as Factor Risk for Threshold ROP . Invest. Ophthalmol. Vis. Sci. 2003;44(13):592.

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Abstract

Abstract: : Purpose: To determine the association between Candida Infection and threshold and Retinopathy of Prematurity (ROP). Methods: from Oct ‘94 to Jun '02 210 inborn preterm neonates, with gestational age (GA) ≤30 weeks and/or a birth weight (BW) ≤1250gr, were screened for ROP in our neonatal intensive care unit. The mean BW was 818.0± 212 grams (range 390-1120) and the mean GA was 27.7± 1.5 weeks (range 23-30w). Candida infection was defined as positive blood, urine or CSL culture or pneumonia (Bronchoalveolar fluid lavage positive for candida) or a combination of previous and clinical evidence for sepsis. Results: ROP was diagnosed in 150 preterms (71.43%). Stage 1 or 2 ROP were detected in 85 (55,36% of all ROP), stage 3 was found in 38 babies (25.3%), while 27 infants (12.86%) reached threshold and underwent surgical procedure. Among all screened babies 21 underwent candida infection. Their mean GA was 27.0± 1.5 weeks (range 24-30) and mean BW was 818± 212 grams (range 390-1120). Despite similar mean BW and GA the severity of ROP was greater in the candida-infected infants than in the whole population. In fact, 19 of 21 babies with candida infection (90.48%) showed any stage of ROP, and 10 of them (52.63%) progressed toward a threshold ROP and required treatment. ROP as well as threshold ROP have significantly higher prevalence on preterm infants with candida infection as compared with non-infected infants (p<0.0001). The authors discuss about the possible mechanisms of such association on the basis of neonatal and ophthalmologic parameters. Conclusions: In preterm infants with candida infection the prevalence of threshold ROP was more than 4-fold higher than that of non-infected infants. Candida infection could not be a causal factor, but could be a marker for infants with a complicated neonatal course who are at risk of developing threshold ROP.  

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Keywords: retinopathy of prematurity • fungal disease • clinical (human) or epidemiologic studies: ris 
© 2003, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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