OCT and FA in the Follow-Up of PDT Treatment of CNV in Myopic Patients

Abstract

Abstract: : Purpose: In pathologic myopia fluorescein angiography (FA) shows great difficulty in objective leakage evaluation, especially in patients treated with photodynamic therapy (PDT) for subfoveal choroidal neovascularization (CNV). Aim of our study was to know if OCT may add information to FA to identify the presence of subretinal exudation in myopic patients treated with PDT in order to decide the retreatment. Methods: 51 consecutive myopic patients, previously underwent at one PDT treatment, were enrolled from January 2002 through October 2002. Patients underwent complete ocular examination, medical history, FA and OCT. Complete control sessions were planned every three months. 40 out of the 51 patients underwent follow up . OCT and FA were performed and evaluated by two masked operators. Results: At the first examination, one week after the PDT , the two tests presented a good concordance ( K: 0.72 – 95% CI: 0 – 089- 0.911). Leakage from FA corresponded to presence of exudation in OCT images. At the first control the concordance resulted poor ( K: 0.35). At the second control the concordance resulted inferior (K: 0.23). At the third control after about nine months the concordance comes backs good (K : 0.70 Conclusions: OCT was more sensitive than FA in detecting exudation in the follow up. We can hypothesise that OCT could add important information in the follow-up of myopic patients treated with PDT and could improve our behaviour in the choice of the retreatment.

Keywords: choroid: neovascularization • myopia • photodynamic therapy