May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Cancer-associated Retinopathy: The First Case Associated with Multiple Myeloma
Author Affiliations & Notes
  • P.A. Brannan
    Ophthalmology, Univ Cincinnati, Cincinnati, OH, United States
  • K.C. Golnik
    Ophthalmology, Univ Cincinnati, Cincinnati, OH, United States
  • D.T. Hudak
    Ophthalmology, Univ Cincinnati, Cincinnati, OH, United States
  • Footnotes
    Commercial Relationships  P.A. Brannan, None; K.C. Golnik, None; D.T. Hudak, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 636. doi:
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      P.A. Brannan, K.C. Golnik, D.T. Hudak; Cancer-associated Retinopathy: The First Case Associated with Multiple Myeloma . Invest. Ophthalmol. Vis. Sci. 2003;44(13):636.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:To report the first case of multiple myeloma-associated retinopathy with serologic confirmation of antiretinal antibodies Methods:Chart review Results:A 57 year old caucasion woman presented with bilateral blurry vision which rapidly progressed to bare light perception on the left and 20/70 on the right. The exam was significant for mild bilateral optic nerve pallor, anterior vitreous cells, and severe constriction of the right visual field. Testing was significant for a flat ERG. A presumptive diagnosis of cancer-associated retinopathy was made although no history of cancer was present. An extensive oncologic work-up was negative. Laboratory evaluation for cancer-related antiretinal antibodies was negative, but Western blot reactions and indirect immunohistochemistry were positive for antibodies against multiple retinal proteins. The patient later developed multiple myeloma. Conclusions:Multiple myeloma can indirectly cause retinal damage and severe visual loss by inducing formation of antiretinal antibodies.

Keywords: neuro-ophthalmology: diagnosis • retina: distal(photoreceptors, horizontal cell 
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