May 2003
Volume 44, Issue 13
ARVO Annual Meeting Abstract  |   May 2003
Ocular Surface Changes in Keratoconjunctivitis Sicca With Silicone Punctum Plug Occlusion
Author Affiliations & Notes
  • A. Pelit
    Ophthalmology, Ba
  • D. Dursun
    Ophthalmology, Ba
  • Y.A. Akova
    Ophthalmology, Ba
  • B. Bilezikci
    Pathology, Ba
  • A. Ertan
    Pathology, Ba
  • Footnotes
    Commercial Relationships  A. Pelit, None; D. Dursun, None; Y.A. Akova, None; B. Bilezikci, None; A. Ertan, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 697. doi:
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      A. Pelit, D. Dursun, Y.A. Akova, B. Bilezikci, A. Ertan; Ocular Surface Changes in Keratoconjunctivitis Sicca With Silicone Punctum Plug Occlusion . Invest. Ophthalmol. Vis. Sci. 2003;44(13):697.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: To evaluate histopathologic response to plug insertion in dry eye patients. Methods: Punctal plugs were placed in 32 eyes of 18 dry eye patients with aqueous deficiency who were on maximum medical therapy and who had Schirmer testing with topical anesthetic measuring less than 5 mm. Pre-treatment and post- treatment (6 weeks and 1 year) evaluations included temporal and inferior quadrant impression cytology examinations, Schirmer-1, BUT, corneal fluorescein and rose-bengal staining patterns and questionnaire scores. The cytology samples were graded according to the method described by Nelson. Results: There was an improvement in subjective symptoms of patients after punctal occlusion. Corneal fluorescein and rose-bengal staining scores decreased from a mean of 5.33±1.74 to 1.37±1.48 and from 5.9.0± 1.2 to 2.45±1.89 (p<0.001) respectively. BUT values increased from 2.98±1.1 to 11.3±3.1 seconds (p<0.001) at 6 weeks post-treatment. Increase in goblet cell density was observed after punctal occlusion at 6 weeks (p<0.05) and at 1 year (p<0.05) compared to the pre-treatment values. 44% of temporal specimens were Grade 1, 50% were Grade 2 and 6% were Grade 3 whereas 3% of inferior specimens were recorded as Grade 0, 41% were Grade 1, 56% were Grade 2 before punctal plugs were inserted. After occlusion, 3% of temporal specimens were Grade 0, 63% were Grade 1, 34% were Grade2 and 25% of inferior specimens were Grade 0, 56% were Grade 1, 19% were Grade 2. Conclusions: Punctum plug occlusion in keratoconjunctivitis sicca provides improvement of tear film stability, decrease of ocular surface staining scores, squamous metaplasia grades and increase of goblet cell density. Increased ocular surface exposure to essential tear components with punctal occlusion may be important for the genesis of these changes.

Keywords: conjunctiva • inflammation • cytology 

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