May 2003
Volume 44, Issue 13
ARVO Annual Meeting Abstract  |   May 2003
Clinical and Linkage Study of a Family with Simple Ectopia Lentis
Author Affiliations & Notes
  • R. Sui
    Ophthalmology, Peking Union Med Coll, Beijing, China
  • H. Wei
    Eent, No. 252 Hospital, Baoding, China
  • B. Wang
    Eent, No. 252 Hospital, Baoding, China
  • J. Zhao
    Eent, No. 252 Hospital, Baoding, China
  • Footnotes
    Commercial Relationships  R. Sui, None; H. Wei, None; B. Wang, None; J. Zhao, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 802. doi:
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      R. Sui, H. Wei, B. Wang, J. Zhao; Clinical and Linkage Study of a Family with Simple Ectopia Lentis . Invest. Ophthalmol. Vis. Sci. 2003;44(13):802.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: A large family with simple ectopia lentis was investigated clinically and analyzed by linkage to markers in the region of FBN1, the gene related to Marfan syndrome. Methods: Anterior and posterior segment of the eyes, height, arm span and echocardiogram were examined for the family. The comparison was made between the affected and the unaffected members. Specific markers for the FBN1were selected for linkage study. Results: This is an anotosomal dominant trait in this family.No patient had clinical or echocardiographic abnormality. The FBN1 region was not excluded. Conclusions: More markers flank were needed to confirm the results. The ectopia lentis gene in this family is likely to be allelic to Marfan syndrome.


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