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A. Sakamoto, H. Sasaki, F. Jonasson, A. Fujisawa, M. Kojima, K. Kitagawa, N. Takahashi, K. Sasaki, Reykjavik Eye Study Group; Prevalence of Cornea Guttata in Iceland -Reykjavik Eye Study . Invest. Ophthalmol. Vis. Sci. 2003;44(13):815.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To establish the prevalence of Cornea Guttata (CG) in the Icelandic population 55 years and older. Methods: The Reykjavik Eye Study (RES) is a population based study using the population census. The 1045 subjects who participated in the RES in 1996 were reexamined 5 years later in 2001. 846 persons or 88% of survivors participated again in the RES in 2001. Among the 846 participants, 1527 eyes of 774 cases (68.3±8.5 years old) without any history of intraocular surgery, trauma, corneal disease and uveitis were selected as subjects for the current study. Examination for CG was done by a single observer with both slitlamp and specular microscopy (Noncon ROBO, Konan). Corneal endothelial changes were analyzed by specular microscopy and the thickness of the cornea was also measured. CG were divided into five grades according to the area of dark spots in the central part of the cornea as follows; Grade 1 (0%), Grade 2 (less than 10%), Grade 3 (10- 25%), Grade 4 (25-50%) and Grade 5 (more than 50%). Results: The observed prevalence of CG was 12.1%. It was significantly higher in females (15.1%) than in males (5.5%). The prevalence of CG increased with aging. The average cell density (CD), coefficient of variation in cell size (CV) and the ratio of hexagonal cells (RH) in CG and non-CG was 2315/mm2 and 2475/mm2, 55.5 and 59.0, and 41.3% and 36.1%, respectively (p<0.01). The CD and RH decreased and the CV increased with increasing grades of CG. No significant difference was seen in the thickness of the cornea between CG and non-CG groups. Conclusions: The prevalence of CG in the Icelandic population was established. The prevalence of CG increased with aging and was more prevalent in females than in males. There was a positive correlation between the severity of CG and the areas of dark spots.
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