May 2003
Volume 44, Issue 13
ARVO Annual Meeting Abstract  |   May 2003
Ciliary Oxygen Tension, Ciliary Blood Flow and Brimonidine
Author Affiliations & Notes
  • H.A. Reitsamer
    Dept of Physiology, Univ Vienna Med School, Vienna, Austria
  • J.W. Kiel
    Dept of Ophthalmology, UTHSCSA, San Antonio, TX, United States
  • Footnotes
    Commercial Relationships  H.A. Reitsamer, None; J.W. Kiel, None.
  • Footnotes
    Support  EY09702, FWFJ1866-MED, San Antonio Lions Club, Lions International, Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 959. doi:
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      H.A. Reitsamer, J.W. Kiel; Ciliary Oxygen Tension, Ciliary Blood Flow and Brimonidine . Invest. Ophthalmol. Vis. Sci. 2003;44(13):959.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: To measure oxygen tension (PO2) and blood flow (CBF)in the ciliary body simultaneously and to investigate the effectof brimonidine on these two parameters. Methods: All experimentswere performed in anesthetized new Zealand white rabbits (n=7).For measurements of oxygen tension, oxygen sensitive microelectrodeswere advanced through a scleral window and placed in the vicinityof the ciliary body. CBF was measured by laser Doppler flowmetry,intraocular pressure (IOP) was measured via direct cannulationof the vitreous and mean arterial pressure (MAP) was measuredthrough a catheter in the ear artery. Brimonidine was appliedtopically on the cornea (40 µl, 0.15 %) Results: 

Brimonidine lowered IOP, CBF andPO2 significantly, however, no significant effect on MAP wasobserved. Conclusions: It is possible to measure ciliary PO2and ciliary blood flow simultaneously in this rabbit model.Despite the increase in perfusion pressure (MAP-IOP), CBF wasdecreased by brimonidine which indicates it is a potent vasoconstrictorin the ciliary circulation. In addition, it reduces PO2 measuredin the vicinity of the ciliary processes. Baseline changes  

Keywords: ciliary body • blood supply • hypoxia 

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