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J.S. Schuman, T.H. Ko, J.G. Fujimoto, C. Mattox, L. Paunescu, H. Ishikawa, G. Wollstein, W. Drexler, A.M. Kowalevicz, I. Hartl; Comparative Study of Glaucoma Using Ultrahigh Resolution and Standard Optical Coherence Tomography . Invest. Ophthalmol. Vis. Sci. 2003;44(13):976.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To perform a comparative imaging study of glaucoma using ultrahigh resolution (UHR) optical coherence tomography (OCT) versus standard resolution OCT. To investigate cases where the improved visualization of UHR OCT yields improved information on glaucomatous retinal and optic nerve damage. To apply UHR OCT results to improve the interpretation of standard resolution OCT images. Methods: A new ultrahigh resolution UHR OCT system has been developed which enables imaging in the ophthalmic clinic using a high performance, low cost, compact femtosecond laser light source. The UHR OCT instrument achieves axial image resolutions of better than 3 µm and image sizes of 3000 axial pixels by 600 transverse pixels. Comparative studies are performed using a commercial OCT3 instrument (Carl Zeiss Meditec, Dublin, CA) with a 10-15 µm axial resolution. UHR and standard resolution OCT imaging are performed in the same patients and results correlated with standard clinical examination including stereoscopic biomicroscopy of the retina, nerve fiber layer and optic nerve head, stereoscopic optic nerve head photography and nerve fiber layer photography and automated perimetry. Results: To date, more than 40 eyes of 25 patients have been imaged with a wide spectrum of glaucoma damage with both UHR and standard resolution OCT. The improved axial resolution of the UHR OCT enables better visualization of intraretinal architectural morphology than standard resolution OCT. UHR OCT is especially powerful for visualizing pathology of the macular ganglion cell and nerve fiber layers, which are difficult to see with standard resolution. UHR imaging highlights the pathology of glaucomatous optic neuropathy. At the same time, UHR OCT provides a baseline for interpreting features seen with standard resolution OCT. Conclusions: UHR OCT enables better visualization of glaucoma pathologies than standard resolution OCT and is especially powerful for elucidating changes in intraretinal architectural morphologies associated with various stages of glaucoma. Comparative studies of UHR and standard resolution OCT also provide a baseline for better interpretation of standard resolution OCT.
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