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D.F. Garway-Heath, D.S. Greenfield, J. Caprioli; Correlation of Visual Field Sensitivity and Retinal Nerve Fibre Layer Thickness as Measured by Scanning Laser Polarimetry . Invest. Ophthalmol. Vis. Sci. 2003;44(13):980.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: to evaluate the strength and pattern of the correlation between visual field (VF) sensitivity and retinal nerve fibre layer thickness (RNFLT) measurements by scanning laser polarimetry with variable (eye-specific) corneal compensation. Methods: 54 eyes of 54 normal subjects (mean ± standard deviation: age 42 ± 15 years, VF mean deviation (MD) -0.69 ± 1.01 dB) and 51 eyes of 51 glaucoma patients (age 66 ± 14 years, VF MD -6.92 ± 5.43 dB) were imaged with a scanning laser polarimeter with a prototype variable corneal compensator. Images were acquired with two compensator settings: fixed (population mode) "FCC" and variable (eye-specific) "VCC". VF pointwise sensitivity was recorded in dB (dB = 10*log[1/L]) and 1/L scales. Linear and logarithmic correlations were sought between global and sectoral (Garway-Heath et al, Ophthalmology 2000) VF sensitivty (dB and 1/L scales) and RNFLT measurements. Correlations of VF sensitivity and RNFLT with age were also sought in normal subjects. Results: Both VF sensitivity (p<0.001) and RNFLT (p=0.005) declined with age. VCC global (R2 = 0.49) and sectoral (R2 = 0.00 to 0.47) RNFLT correlations with VF sensitivity were significantly greater than FCC global (R2 = 0.12) and sectoral (R2 = 0.00 to 0.21) correlations. There was no correlation between VF sensitivity and RNFLT in the temporal sector. The strongest relationship was found in the supero-nasal sector. Logarithmic regression of dB VF sensitivity against RNFLT was significantly better than linear regression, except for the supero-nasal sector. Linear regression of 1/L VF sensitivity against RNFLT was significantly better than logarithmic regression for all sectors. R2 values for 1/L linear regressions were generally greater than dB logarithmic regressions. Conclusions: RNFLT measurements by scanning laser polarimetry with variable (eye-specific) corneal compensation correlate well with VF sensitivity. Correlations were linear with the 1/L scale for VF sensitivity and curvilinear (logarithmic) with the dB scale. R2 values were higher with the 1/L scale.
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