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G.B. van Setten, M. Aspiotis, T.D. Blalock, G. Grotendorst, G.S. Schultz; Detection of Connective Tissue Growth Factor (CTGF) in Pterygium . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1325.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To investigate the presence of CTGF in pterygia and its localization in relation to vascular endothelial growth factor (VEGF). Methods: Samples pterygia were collected during surgery with informed consent of 20 patients. Specific antibodies against CTGF were used to detect CTGF using immuno-histochemistry. The same specimes were stained with commercial antibodies for VEGF. Results: Intense staining for CTGF was detected in the epithelium of all samples of pterygium. Even some stromal keratocytes expresed CTGF. Also VEGF was detected in all samples but staining pattern differed slightly. The control sections were negative. Conclusions: It was shown that CTGF is present in the epithelium of pterygia whereas is appears to be absent in normal conjunctiva. The expression of CTGF in pathological conditions may indicate a contribution of this growth factor to th pathology of pterygium by its involvement in fibrosis. The simultaneous presence with VEGF suggests growth factor interaction the details of which need to be clarified.
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