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S.A. Schellini, E. Hoyama, C.E. Bacchi, C.R. Padovani, D.E. Oliveira; Matrix Metalloproteinase-9 (MMP-9) Expression in Pterygium . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1328.
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Purpose:to evaluate the presence and expression of MMP-9 in pterygium. Methods: a prospective randomized clinical trial took place at the Botucatu School of Medicine (São Paulo-Brazil). The pterygium lesion and a fragment of normal conjunctiva (control group) of the same eye from 61 patients were excised and submitted to immunohistochemical evaluation for detection of MMP-9 expression. The mean age was 51.62 year-old. Forty-two lesions were primary pterygium and 19 recurrent pterygium. The data were submitted to a computerized image analysis system and statistical analysis. Results: the MMP-9 evaluation showed similarity in expression between the control and pterygium groups. Difference of expression was also not observed between the primary and recurrent pterygium. Conclusion:the MMP-9 is present in the conjunctiva tissue and its expression is similar in pterygium and in normal conjunctiva and there was not observed difference of expression among the types of pterygium evaluated.
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