May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Limbal Stem Cells Deficiency Associated with LADD Syndrome
M. Cortes; A. Lambiase; M. Sacchetti; S. Aronni; R. Sgrulletta; S. Bonini
Author Affiliations & Notes
  • M. Cortes
    Ophthalmology, University Rome Campus Bio-Medico, Rome, Italy
  • A. Lambiase
    Ophthalmology, University Rome Campus Bio-Medico, Rome, Italy
  • M. Sacchetti
    Ophthalmology, University Rome Campus Bio-Medico, Rome, Italy
  • S. Aronni
    Ophthalmology, University Rome Campus Bio-Medico, Rome, Italy
  • R. Sgrulletta
    Ophthalmology, University Rome Campus Bio-Medico, Rome, Italy
  • S. Bonini
    Ophthalmology, University Rome Campus Bio-Medico, Rome, Italy
  • Footnotes
    Commercial Relationships  M. Cortes, None; A. Lambiase, None; M. Sacchetti, None; S. Aronni, None; R. Sgrulletta, None; S. Bonini, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 1379. doi:
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      M. Cortes, A. Lambiase, M. Sacchetti, S. Aronni, R. Sgrulletta, S. Bonini; Limbal Stem Cells Deficiency Associated with LADD Syndrome . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1379.

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Abstract

Abstract: : Purpose:to evaluate ocular surface changes in patients with LADD syndrome including cytological evaluation of the corneal epithelium. Methods: a complete study of the ocular surface was performed in two patients (mother and daughter) affected by LADD syndrome, including corneal and conjunctival impression cytology to detect goblet cells and cytokeratin pattern, corneal aesthesiometry (by Cochet-Bonnet) and, in the mother, hematological exams and conjunctival biopsy. Results: in both patients limbal stem cell deficiency (LSCD) and corneal hypo-anesthesia were present. Histological findings showed the presence of total (presence of goblet cells and K19 positive cells on the whole corneal surface) and partial (presence of goblet cells and K19 positive cells only on the inferior corneal sector) LSCD in the mother and the child respectively. Schirmer-I test, BUT test, and conjunctival cytology showed the presence of dry eye in the mother but not in the daughter. In addition, an increase in circulating immunocomplexes was present in the mother. Conjunctival biopsy showed histopathological changes related to dry eye in the mother. Conclusions: the ocular involvement in LADD syndrome cannot be considered solely related to dry eye but is probably the result of ocular surface changes such as LSCD and corneal sensitivity impairment.

Keywords: cornea: clinical science • cornea: epithelium • cytology 
© 2003, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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