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Y. Hotta, N. Tomita, K. Koide, T. Tsuchiya, N. Hata, M. Kato, M. Nakamura, Y. Miyake; Sectorial Fundus Albipunctatus Is Not Associated With RDH5 Gene Mutation . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1471.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To report a case of sectorial fundus albipunctatus not associated with RDH5 gene mutation. Methods: A 51-year-old woman showed multiple yellow-white flecks similar to those of fundus albipunctatus in only the upper half of the retina in both eyes. We performed clinical, electrophysiological, and molecular genetic examinations. Results: Her visual acuities were 20/20 with –2.5D -0.75D X 90° OD, and 20/20 with –1.75D -0.75D X 95° OS. No remarkable visual field defect was detected by the Goldmann perimetry. Fluorescein angiography showed diffuse irregular hypofluorescence which did not correspond with the fleck lesions. The Goldmann-Weeker adaptometer test revealed that visual threshold of the upper retina was approximately 0.6 to 0.8 log units higher than that of the lower retina. No abnormal pattern and differences in the full-field and multifocal ERG. No mutations of the RDH5 gene was detected in exons 2-5 as well as the flanking intron sequences. Conclusions: To our knowledge, this is the first report of sectorial fundus albipunctatus, and the flecks may be not caused by the RDH5 gene mutation.
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