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M. Völker, W. Inhoffen, F. Gelisken, K.U. Bartz-Schmidt; Functional and Morphological Outcomes after Verteporfin Photodynamic Therapy (PDT) for Circumscribed Chorioidal Haemangioma (CCH) . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1587.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:: To describe the functional and morphological outcome of different verteporfin-PDT treatments for CCH. Methods:: Three eyes of 3 patients (1 male, 2 female, age 43-52 years) with CCH (extrafoveal, height 1.9-3.3 mm, noticed central shadow since 3-4 months due to subfoveal neurosensory detachment (NSD) without foveal edema, initial visual acuity 20/50-20/25 ) were treated by single spot verteporfin-PDT, two of them with 600 mW/cm² (A) and one with 300 mW/cm² (B), other parameters identical to standard protocol of treatment for chorioidal neovascularization in age related macula degeneration. Examination included ultrasonography, color photography, fluorescein and indocyanine green angiography and optical coherence tomograpy, performed before treatment and after 2 weeks and was repeated every three months. Scanning Laser Ophthalmoscope (SLO, Rodenstock Instruments, Germany) was used for assessment of central scotoma. Primary outcomes were change in visual acuity, NSD and tumor height. Follow up was 1-1.5 years. Results:: No re-treatment was necessary. Visual acuity improved in all patients. Tumor height decreased to 0 mm (method A) and decreased slightly from 1.9 mm to 1.4 mm (method B). In contrast, NSD resolved completely in all cases and noticed central shadow disappeared. Thus, all patients now reported no more complaints. SLO-microperimetry revealed in one eye a dense extrafoveal scotoma, which was reduced in area after therapy (A). The other patients did not show a scotoma before and after therapy. Conclusions: The results of these treatments show that PDT is a useful method to treat CCH and in addition, development of tumor height after therapy seems to be not the only important factor for re-treatment: in selected cases without long standing NSD, reduced laser intensity may be sufficient to resolve the NSD - which is one of the most important reasons for decreased VA - completely.
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