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C.A. Applegate, J. Chao, A.S. Zucherbrod, J.S. Sunness; Decline of Reading Rate Over Time in Geographic Atrophy from AMD . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1788.
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Purpose: To determine the course of reading rate decline in patients with geographic atrophy (GA) from age-related macular degeneration. Methods: One hundred fifty eight patients with GA in one or both eyes were enrolled in a natural history study, in which there was annual follow-up with visual function testing and clinical evaluation. Reading was measured using a paragraph of unrelated words, for which the normal elderly reading rate is 125 words or greater. Reading rate was measured for 9 character sizes based on visual acuity. Results: Thus far, data have been analyzed from 51 eyes of patients who completed the second follow-up visit. For those who began with maximum reading rates of 100 words per minute (wpm) or greater at baseline, the mean maximum reading rate at the second follow-up visit was 49% of the baseline value (n=21). For those who had maximum reading rates of 50-99 wpm at baseline, the mean maximum reading rate at the second follow-up visit was 71% of the baseline value (n=16). For those with maximum reading rates of 20-49 wpm at baseline, the mean maximum reading rate at the second follow-up visit was 65% of the baseline value (n=14). Conclusions: Reading rate continues to decline over time in patients with GA even when reading rate was low at baseline. The largest % decrease in reading rate was in those with baseline reading rates >=100 wpm. Possible therapeutic intervention could be beneficial at all stages of the disease.
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