May 2003
Volume 44, Issue 13
ARVO Annual Meeting Abstract  |   May 2003
Feasibility of ERG in Senescence-accelerated Mouse (SAM)
Author Affiliations & Notes
  • A.M. Bron
    Department of Ophthalmology, University Hospital, Dijon, France
  • J. Chardigny
    Lipid Nutrition Unit, INRA, Dijon, France
  • N. Acar
    Lipid Nutrition Unit, INRA, Dijon, France
  • C.P. Creuzot-Garcher
    Lipid Nutrition Unit, INRA, Dijon, France
  • J. Sebedio
    Lipid Nutrition Unit, INRA, Dijon, France
  • Footnotes
    Commercial Relationships  A.M. Bron, None; J. Chardigny, None; N. Acar, None; C.P. Creuzot-Garcher, None; J. Sebedio, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 1893. doi:
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      A.M. Bron, J. Chardigny, N. Acar, C.P. Creuzot-Garcher, J. Sebedio; Feasibility of ERG in Senescence-accelerated Mouse (SAM) . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1893.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: The senescence-accelerated mouse (SAM) is a model of aging. The aim of this study was to investigate the feasibility of in vivo ERG in two SAM strains: SAMP8 and SAMR1. Methods: Six month-old animals were anaesthetized and the ERG was recorded via the silver corneal electrode and a reference electrode placed on the tongue. The ERG response was amplified using a low-pass filter setting of 1 Hz and a high-pass filter of 1,000 Hz. After amplification, the signal was digitized and processed. The retina was stimulated by a photostimulator delivering light flashes (white light, 10 µsec, 237 lx) to the eye by optical fibers and a white sphere that mimics a Ganzfeld dome. Results: No statistical differences were observed between both strains for these parameters. Optic microscopy was also performed to assess the structure of retina. Conclusion: This preliminary study shows that in vivo ERG in the senescence-accelerated mouse is feasible in routine. Further experiments are ongoing with older animals to establish an age related evolution of ERG in these SAM strains.  

Keywords: electroretinography: non-clinical • aging • animal model 

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