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Y. Nakamura, Y. nakamura, H. Sakai, S. Sawaguchi; Chamber Angle Pigmentation after Long Term Latanoprost Treatment for Glaucoma . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2205.
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Purpose: To examine prospectively the change of chamber angle pigmentation and the efficacy of latanoprost in the long-term treatment for glaucoma patients for 3 years. Patients and Methods: Forty-one Japanese glaucoma patients of ocular hypertension, primary open angle glaucoma and normal tension glaucoma were treated with latanoprost for more than 36 months.Gonioscopic photographs of lower quadrant were taken in all patients at pre-latanoprost treatment, at every 3-months for 1 year and every 6-months for 2 years after latanoprost treatment. 3 glaucoma specialists examined Gonioscopic photographs after 3 years follow up in a masked manner. Intra ocular pressure (IOP) was measured over the 36-months treatment period, and adverse events were evaluated. Results: No pigmentary change at chamber angle was observed for 36 months follow up period. Ten patients showed increased iris pigmentation and 3 cases showed eyelash changes. Latanoprost significantly reduced (PÅÉ0.001) IOP by approximately 3.6mmHg from initial pretreatment value at 3 months and this reduction continued over 36-months without signs of upward drift. Conclusions: Latanoprost, administered once daily, did not give any pigmentary change at chamber angle in all 41 glaucoma patients, even in 10 patients with increased iris pigmentation for 3 years. Latanoprost is also effective on lowering IOP for Japanese glaucoma patients up to 3 years.
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