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H. Sato, H. Tomita, S. Wakana, M. Tamai; Isolation and Characterization of a Novel Gene in Retina: Deleted in Polyposis 1-Like 1 . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2264.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To isolate and characterize a novel gene in retina. Methods:A systemic screening by subtraction hybridization between the cDNAs from mouse retina and mouse brain. Results:We isolated a novel gene, designated as deleted in polyposis 1-like 1 gene (Dp1l1), that is expressed abundantly in the retina. It encodes a 201 amino acid protein, which is highly homologous to the protein encoded by the deleted in polyposis 1 gene (Dp1). In situ hybridization and immunohistochemical analysis showed that Dp1l1 mRNA and the encoded protein were localized richly in the ganglion cell layer. The Dp1l1 gene was mapped to mouse chromosome 10 by radiation hybrid mapping. Conclusions:We propose that Dp1l1 may be a candidate gene for ophthalmic disorders such as optic atrophy in which retinal ganglion cells are involved.
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