May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Porcine Acellular Dermal Graft and Impermeable Dressing in the Treatment of Full-Thickness Wounds in a Rat Model
Author Affiliations & Notes
  • E. Hoyama
    Ophthalmology, Botucatu School of Medicine, Botucatu, Brazil
  • S.A. Schellini
    Ophthalmology, Botucatu School of Medicine, Botucatu, Brazil
  • M.E. Marques
    Pathology, Botucatu School of Medicine, Botucatu, Brazil
  • R. Rossa
    Head and Neck Surgery, University of São Paulo, São Paulo, Brazil
  • C.R. Padovani
    Biostatistics, Botucatu School of Medicine, Botucatu, Brazil
  • Footnotes
    Commercial Relationships  E. Hoyama, None; S.A. Schellini, None; M.E.A. Marques, None; R. Rossa, None; C.R. Padovani, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 2444. doi:
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      E. Hoyama, S.A. Schellini, M.E. Marques, R. Rossa, C.R. Padovani; Porcine Acellular Dermal Graft and Impermeable Dressing in the Treatment of Full-Thickness Wounds in a Rat Model . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2444.

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Abstract

Abstract: : Purpose: The purpose of this study is to evaluate the clinical and inflammatory response elicited by a porcine derived acellular dermal graft (PADG) associated to an impermeable polyethylene gel derived dressing (I) in the treatment of full-thickness wounds in a rat model. Methods: Two full-thickness wounds were surgically created along the dorsal midline of 16 rats (4 rats/group). The PADG associated to the I (G1) was placed superiorly and the PADG alone (G2), inferiorly. During the postoperative (PO) period, the implants received collagenase ointment twice daily until the sacrifice. The wounds were clinically evaluated by photos and the PADGs and surrounding soft tissues were assessed for histological evaluation at 07, 15, 30 and 60 PO days. Results: The impermeable dressing persisted associated to the PADG until a maximum period of 15 days. Clinically, the G1 presented less desiccation than the G2. The light microscopy showed an ulcerous formation covered by a fibrin crust and edema, inflammatory cell infiltrate and red cells in the dermis greater in G2 than in G1. At the 60 PO day, the G1 presented an epithelium similar to the normal. However, in the G2, ulcerous formation, an irregular and thin epithelium and lack of queratin were still observed. Conclusions: The PADG associated to the impermeable dressing presented better clinical and histological results than the PADG alone in the treatment of full-thickness wounds healing.

Keywords: wound healing • animal model • pathology: experimental 
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