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Y.H. Choi, J.C. Affeldt, K. Schneider; Corneal Intraepithelial Neoplasia Following LASIK . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2620.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To document for the first time development of, treatment, and outcome for corneal intraepithelial neoplasia (CIN) following LASIK. Methods: Case report Results: A 70 year-old Caucasian male developed ocular surface changes OD consistent with CIN two years following bilateral LASIK surgery. The peninsular-shaped fibrinated edged lesion emanated from the head of a small temporal pterygium, and crossed the LASIK flap margin with broad margins encroaching upon the visual axis. The lesion did not demonstrate lamellar flap invasion. Within four weeks of slit-lamp controlled #15 blade excisional surface debridement and local pterygium excision, multiple foci of recurrence became apparent within the flap boundaries. Six months after more aggressively applied repeat #15 blade debridement, the cornea remained clear with no evidence of recurrence. No flap edge or intralamellar complications were encountered at any time. Histologic exam revealed mild to moderate epithelial dysplasia with scattered mitotic figures consistent with the diagnosis of CIN. Conclusions: Post-LASIK CIN with flap zone and margin involvement can be successfully treated with standard excisional debridement techniques without creating flap and intralamellar complications.
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